PUBLICATIONS

Research Articles (selected)


  • Tominari T, Matsumoto C, Tanaka Y, Shimizu K, Takatoya M, Sugasaki M, Karouji K, Kasuga U, Miyaura C, Miyata S, Itoh Y, Hirata M, Inada M. Roles of Toll-like Receptor Signaling in Inflammatory Bone Resorption. Biology. 2024 Sep 13(9):692. doi.org/10.3390/biology13090692.
  • Urano K, Tanaka Y, Tominari T, Takatoya M, Arai D, Miyata S, Matsumoto C, Miyaura C, Numabe Y, Itoh Y, Hirata M, Inada M.The stiffness and collagen control differentiation of osteoclasts with an altered expression of c-Src in podosome.Biochem Biophys Res Commun.2024 Feb 13;704:149636. doi: 10.1016/j.bbrc.2024.149636.
  • Tominari T, Takatoya M, Matsubara T, Matsunobe M, Arai D, Matsumoto C, Hirata M, Yoshinouchi S, Miyaura C, Itoh Y, Komaki H, Takeda S, Aoki Y, Inada M. Establishment of a Triple Quadrupole HPLC-MS Quantitation Method for Dystrophin Protein in Mouse and Human Skeletal Muscle. Int J Mol Sci. 2023 Dec 25;25(1):303. doi: 10.3390/ijms25010303.
    IJMS 2023 Best Paper Award
    TUATプレスリリース
    日本筋ジストロフィー協会プレスリリース
    文教速報デジタル版
  • Hirata M, Tominari T, Ichimaru R, Takiguchi N, Tanaka Y, Takatoya M, Arai D, Yoshinouchi S, Miyaura C, Matsumoto C, Ma S, Suzuki K, Grundler FMW, Inada M. Effects of 4'-Demethylnobiletin and 4'-Demethyltangeretin on Osteoclast Differentiation In Vitro and in a Mouse Model of Estrogen-Deficient Bone Resorption. Nutrients. 2023 Mar 14;15(6):1403. doi: 10.3390/nu15061403.

  • Yoshinouchi S, Karouji K, Tominari T, Sugasaki M, Matsumoto C, Miyaura C, Hirata M, Itoh Y, Inada M. Prostate cancer expressing membrane-bound TGF-α induces bone formation mediated by the autocrine effect of prostaglandin E2 in osteoblasts. Biochem Biophys Res Commun. 2023 Feb 12;644:40-48. doi: 10.1016/j.bbrc.2022.11.050.

  • Yamamoto H, Uchida Y, Kurimoto R, Chiba T, Matsushima T, Ito Y, Inotsume M, Miyata K, Watanabe K, Inada M, Goshima N, Uchida T, Asahara H. RNA-binding protein LIN28A upregulates transcription factor HIF1α by posttranscriptional regulation via direct binding to UGAU motifs. J Biol Chem. 2023 Jan;299(1):102791. doi: 10.1016/j.jbc.2022.102791.

  • Tanaka R, Yoshinouchi S, Karouji K, Tanaka Y, Tominari T, Hirata M, Matsumoto C, Itoh Y, Miyaura C, Inada M.
    A mouse model of lung cancer induced via intranasal injection for anticancer drug screening and evaluation of pathology.FEBS Open Bio. 2023 Jan;13(1):51-59. doi: 10.1002/2211-5463.13486.

  • Matsunobe M, Motohashi N, Aoki E, Tominari T, Inada M, Aoki Y.Caveolin-3 regulates the activity of Ca2+/calmodulin-dependent protein kinase II in C2C12 cells.Am J Physiol Cell Physiol. 2022 Oct 1;323(4):C1137-C1148. doi: 10.1152/ajpcell.00077.2022.

    Tominari T, Akita M, Matsumoto C, Hirata M, Yoshinouchi S, Tanaka Y, Kerouji K, Itoh Y, Maruyama T, Miyaura C, Numabe Y, Inada M. Endosomal TLR3 signaling in stromal osteoblasts induces prostaglandin E2-mediated inflammatory periodontal bone resorption. J Biol Chem.2022 Jan 29;298(3):101603. doi: 10.1016/j.jbc.2022.101603

    TUATプレスリリース ・EurekAlert

  • Tominari T, Samada A, Ichimaru R, Matsumoto C, Hirata M, Itoh Y, Numabe Y, Miyaura C, Inada M. Gram-positive bacteria cell wall-derived lipoteichoic acid induces inflammatory alveolar bone loss through prostaglandin E production in osteoblasts. Sci Rep.2021 Jun 25;11(1):13353. doi:10.1038/s41598-021-92744-5.

    TUATプレスリリース・EurekAlert ・1st Author (日本骨代謝学会)

  • Itoh Y, Ng M, Wiberg A, Inoue K, Hirata N, Paiva KBS, Ito N, Dzobo K, Sato N, Gifford V, Fujita Y, Inada M, Furniss D. A common SNP risk variant MT1-MMP causative for Dupuytren's disease has a specific defect in collagenolytic activity. Matrix Biol. 2021 Mar;97:20-39. doi: 10.1016/j.matbio.2021.02.003.

  • Igarashi K, Yui Y, Watanabe K, Kumai J, Nishizawa Y, Miyaura C, Inada M, Sasagawa S. Molecular evidence of IGFBP-3 dependent and independent VD3 action and its nonlinear response on IGFBP-3 induction in prostate cancer cells. BMC Cancer.2020 Aug 24;20(1):802. doi: 10.1186/s12885-020-07310-5.

  • Tousen Y, Ichimaru R, Kondo T, Inada M, Miyaura C, Ishimi Y. The Combination of Soy Isoflavones and Resveratrol Preserve Bone Mineral Density in Hindlimb-Unloaded Mice. Nutrients. 2020 Jul 9;12(7):2043. doi: 10.3390/nu12072043.

  • Omiya T, Hirose J, Omata Y, Tominari T, Inada M, Watanabe H, Miyamoto T, Tanaka S. Sustained anti-osteoporotic action of risedronate compared to anti-RANKL antibody following discontinuation in ovariectomized mice. Bone Rep. 2020 Jun 5;13:100289. doi: 10.1016/j.bonr.2020.100289.

  • Aharen I, Habash SS, Gleason C, Inada M, Grundler FMW, Elashry AM. Heterodera schachtii glutathione peroxidase (HsGPx) is a parasitism protein. J Plant Dis Protec. 2020 Feb ;127(1):111-118. doi: 10.1007/s41348-019-00256-2.

  • Kim H, Ishibashi K, Matsuo K, Kira A, Okada T, Watanabe K, Inada M, Nakamura C. Quantitative Measurements of Intercellular Adhesion Strengths between Cancer Cells with Different Malignancies Using Atomic Force Microscopy. Anal Chem. 2019 Aug 20;91(16):10557-10563. doi: 10.1021/acs.analchem.9b01569.

  • [Scientific Reports 2019 Top 100 in Cell and Molecular Biology.]
    Tominari T*, Ichimaru R*, Taniguchi K, Yumoto A, Shirakawa M, Matsumoto C, Watanabe K, Hirata M, Itoh Y, Shiba D, Miyaura C, Inada M. Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice. Sci Rep. 2019 Apr 29;9(1):6614. doi: 10.1038/s41598-019-42829-z. *Contributed equally

    TUATプレスリリース・EurekAlert・1st Author (日本骨代謝学会)・日本経済新聞電子版・日刊工業新聞電子版

  • Hirata N*, Ichimaru R*, Tominari T, Matsumoto C, Watanabe K, Taniguchi K, Hirata M, Ma S, Suzuki K, Grundler FMW, Miyaura C, Inada M. Beta-Cryptoxanthin Inhibits Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption via the Suppression of Inhibitor of NF-κB Kinase Activity. Nutrients. 2019 Feb 10;11(2):368. doi: 10.3390/nu11020368. *Contributed equally

  • Hirata N, Tominari T, Ichimaru R, Taniguchi K, Matsumoto C, Watanabe K, Hirata M, Ma S, Suzuki K, Grundler FMW, Miyaura C, Inada M. Structure-activity relationship of anthocyanidins as an inhibitory effect on osteoclast differentiation. BPB Rep. 2019 Jan;2(1):1-6. doi: 10.1248/bpbreports.2.1_1.

  • Aizawa M, Watanabe K, Tominari T, Matsumoto C, Hirata M, Grundler FMW, Inada M, Miyaura C. Low Molecular-Weight Curdlan, (1→3)-β-Glucan Suppresses TLR2-Induced RANKL-Dependent Bone Resorption. Biol Pharm Bull. 2018;41(8):1282-1285. doi: 10.1248/bpb.b18-00057.

  • Matsumoto S, Tominari T, Matsumoto C, Yoshinouchi S, Ichimaru R, Watanabe K, Hirata M, Grundler FMW, Miyaura C, Inada M. Effects of Polymethoxyflavonoids on Bone Loss Induced by Estrogen Deficiency and by LPS-Dependent Inflammation in Mice. Pharmaceuticals (Basel). 2018 Jan 20;11(1):7. doi: 10.3390/ph11010007.

    Ichimaru R*, Tominari T*, Yoshinouchi S, Matsumoto C, Watanabe K, Hirata M, Numabe Y, Murphy G, Nagase H, Miyaura C, Inada M. Raloxifene reduces the risk of local alveolar bone destruction in a mouse model of periodontitis combined with systemic postmenopausal osteoporosis. Arch Oral Biol. 2018 Jan;85:98-103. doi: 10.1016/j.archoralbio.2017.09.017. Epub 2017 Sep 29. *Contributed equally

  • Tominari T, Ichimaru R, Yoshinouchi S, Matsumoto C, Watanabe K, Hirata M, Grundler FMW, Inada M, Miyaura C. Effects of O-methylated (-)-epigallocatechin gallate (EGCG) on LPS-induced osteoclastogenesis, bone resorption, and alveolar bone loss in mice. FEBS Open Bio. 2017 Nov 15;7(12):1972-1981. doi: 10.1002/2211-5463.12340. eCollection 2017 Dec.

  • Watanabe K, Tominari T, Hirata M, Matsumoto C, Hirata J, Murphy G, Nagase H, Miyaura C, Inada M. Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption. FEBS Open Bio. 2017 Jul 20;7(8):1178-1185. doi: 10.1002/2211-5463.12258. eCollection 2017 Aug.

  • Takeda H, Tominari T, Hirata M, Watanabe K, Matsumoto C, Grundler FMW, Inada M, Miyaura C. Lutein Enhances Bone Mass by Stimulating Bone Formation and Suppressing Bone Resorption in Growing Mice. Biol Pharm Bull. 2017;40(5):716-721. doi: 10.1248/bpb.b16-00897.

  • Matsumoto S, Tominari T, Watanabe K, Kobayashi A, Matsumoto C, Ichimaru R, Yoshinouchi S, Hirata M, Florian M W Grundler, Miyaura C, Inada M. Synthetic polymethoxyflavonoids, nobiletin and heptamethoxyflavone suppress IL-1-induced osteoclast differentiation and resorption. Curr Top Biochem Res. 2017;18:57-63. article.

  • Aizawa M, Tominari T, Watanabe K, Hirata M, Matsumoto C, Miyaura C,Inada M. Green tea catechin, (-)-Epigallocatechin-3-gallate, suppresses TLR2-induced bone resorption by inhibiting prostaglandin E production in osteoblasts. Curr Top Biochem Res.2017;18:27-32. article.

  • Tominari T, Matsumoto C, Watanabe K, Hirata M, Grundler FM, Inada M, Miyaura C. Lutein, a carotenoid, suppresses osteoclastic bone resorption and stimulates bone formation in cultures. Biosci Biotechnol Biochem. 2017 Feb;81(2):302-306. doi: 10.1080/09168451.2016.1243983. Epub 2016 Oct 25.

  • Fujita H, Gomori A, Fujioka Y, Kataoka Y, Tanaka K, Hashimoto A, Suzuki T, Ito K, Haruma T, Yamamoto-Yokoi H, Harada N, Sakuragi M, Oda N, Matsuo K, Inada M, Yonekura K. High Potency VEGFRs/MET/FMS Triple Blockade by TAS-115 Concomitantly Suppresses Tumor Progression and Bone Destruction in Tumor-Induced Bone Disease Model with Lung Carcinoma Cells. PLoS One. 2016 Oct 13;11(10):e0164830. doi: 10.1371/journal.pone.0164830. eCollection 2016.

  • Watanabe K, Hirata M, Tominari T, Matsumoto C, Fujita H, Yonekura K, Murphy G, Nagase H, Miyaura C, Inada M. The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer. J Biol Chem. 2016 Sep 30;291(40):20891-20899. doi: 10.1074/jbc.M116.727875. Epub 2016 Aug 18.

    TUATプレスリリース・1st Author (日本骨代謝学会)

  • Watanabe K, Tominari T, Hirata M, Matsumoto C, Maruyama T, Murphy G, Nagase H, Miyaura C, Inada M. Abrogation of prostaglandin E-EP4 signaling in osteoblasts prevents the bone destruction induced by human prostate cancer metastases. Biochem Biophys Res Commun. 2016 Sep 9;478(1):154-161. doi: 10.1016/j.bbrc.2016.07.075. Epub 2016 Jul 19.

  • Watanabe K, Hirata M, Tominari T, Matsumoto C, Endo Y, Murphy G, Nagase H, Inada M, Miyaura C. BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice. Biochem Biophys Res Commun. 2016 Sep 9;478(1):279-285. doi: 10.1016/j.bbrc.2016.07.027. Epub 2016 Jul 9.

  • Anjam MS, Ludwig Y, Hochholdinger F, Miyaura C,Inada M, Siddique S, Grundler FM. An improved procedure for isolation of high-quality RNA from nematode-infected Arabidopsis roots through laser capture microdissection. Plant Methods. 2016 Apr 26;12:25. doi: 10.1186/s13007-016-0123-9. eCollection 2016.

  • Takeda H, Tominari T, Ichimaru R, Matsumoto C, Watanabe K, Hirata M, Inada M, Miyaura C. Lutein, a carotenoid, inhibits lipopolysaccharide-induced alveolar bone loss associated with inflammation in a mouse model of periodontitis. Curr Top Biochem Res.2016;17:71-76. article.

  • Shimizu M, Noda H, Joyashiki E, Nakagawa C, Asanuma K, Hayasaka A, Kato M, Nanami M, Inada M, Miyaura C, Tamura T. The Optimal Duration of PTH(1-34) Infusion Is One Hour per Day to Increase Bone Mass in Rats. Biol Pharm Bull. 2016;39(4):625-630. doi: 10.1248/bpb.b15-00756. Epub 2016 Jan 28.

  • Nishide Y, Tousen Y, Tadaishi M, Inada M, Miyaura C, Kruger MC, Ishimi Y. Combined Effects of Soy Isoflavones and β-Carotene on Osteoblast Differentiation.Int J Environ Res Public Health. 2015 Oct 28;12(11):13750-13761. doi: 10.3390/ijerph121113750.

  • Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C. Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis.J Biol Chem. 2015 Dec 11;290(50):29781-29793. doi: 10.1074/jbc.M115.669481. Epub 2015 Oct 16.

    TUATプレスリリース

  • Tominari T, Matsumoto C, Watanabe K, Hirata M, Grundler FM, Miyaura C, Inada M. Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice. FEBS Open Bio. 2015 Jun 12;5:522-527. doi: 10.1016/j.fob.2015.06.003. eCollection 2015.

  • Hirata J, Hirai K, Asai H, Matsumoto C, Inada M, Miyaura C, Yamato H, Watanabe-Akanuma M. Indoxyl sulfate exacerbates low bone turnover induced by parathyroidectomy in young adult rats. Bone. 2015 Oct;79:252-258. doi: 10.1016/j.bone.2015.06.010. Epub 2015 Jun 23. Epub 2015 Jun 23.

  • Matsumoto C, Inoue H, Tominari T, Watanabe K, Hirata M, Miyaura C, Inada M. Heptamethoxyflavone, a citrus flavonoid, suppresses inflammatory osteoclastogenesis and alveolar bone resorption. Biosci Biotechnol Biochem. 2015;79(1):155-158. doi: 10.1080/09168451.2014.952616. Epub 2014 Aug 30.

  • Nishide Y, Tadaishi M, Kobori M, Tousen Y, Kato M, Inada M, Miyaura C, Ishimi Y. Possible role of S-equol on bone loss via amelioration of inflammatory indices in ovariectomized mice. J Clin Biochem Nutr. 2013 Jul;53(1):41-48. doi: 10.3164/jcbn.12-123. Epub 2013 Jun 1.

  • Matsumoto C, Ashida N, Yokoyama S, Tominari T, Hirata M, Ogawa K, Sugiura M, Yano M, Inada M, Miyaura C. The protective effects of β-cryptoxanthin on inflammatory bone resorption in a mouse experimental model of periodontitis. Biosci Biotechnol Biochem. 2013;77(4):860-862. doi: 10.1271/bbb.120791.

  • Nishide Y, Tousen Y, Inada M, Miyaura C, Ishimi Y. Bi-phasic effect of equol on adipocyte differentiation of MC3T3-L1 cells. Biosci Biotechnol Biochem. 2013;77(1):201-204. doi: 10.1271/bbb.120677. Epub 2013 Jan 7.

  • Miyamoto S, Koyanagi R, Nakazawa Y, Nagano A, Abiko Y,Inada M, Miyaura C, Asakura T. Bombyx mori silk fibroin scaffolds for bone regeneration studied by bone differentiation experiment. J Biosci Bioeng. 2013 May;115(5):575-578. doi: 10.1016/j.jbiosc.2012.11.021. Epub 2013 Jan 1.

  • Matsumoto C, Oda T, Yokoyama S, Tominari T, Hirata M, Miyaura C, Inada M. Toll-like receptor 2 heterodimers, TLR2/6 and TLR2/1 induce prostaglandin E production by osteoblasts, osteoclast formation and inflammatory periodontitis. Biochem Biophys Res Commun. 2012 Nov 9;428(1):110-115. doi: 10.1016/j.bbrc.2012.10.016. Epub 2012 Oct 12.

  • Abe J, Nagai Y, Higashikuni R, Iida K, Hirokawa T, Nagai H, Kominato K, Tsuchida T, Hirata M, Inada M, Miyaura C, Nagasawa K. Synthesis of vitamin D3 derivatives with nitrogen-linked substituents at A-ring C-2 and evaluation of their vitamin D receptor-mediated transcriptional activity. Org Biomol Chem. 2012 Oct 14;10(38):7826-7839. doi: 10.1039/c2ob26017d.

  • Toriseva M, Laato M, Carpén O, Ruohonen ST, Savontaus E, Inada M, Krane SM, Kähäri VM. MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability. PLoS One. 2012;7(8):e42596. doi: 10.1371/journal.pone.0042596. Epub 2012 Aug 7.

  • Tominari T, Hirata M, Matsumoto C, Inada M, Miyaura C. Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis. J Pharmacol Sci. 2012;119(4):390-394. doi: 10.1254/jphs.11188sc. Epub 2012 Jul 31.

  • Kobayashi M, Watanabe K, Yokoyama S, Matsumoto C, Hirata M, Tominari T, Inada M, Miyaura C. Capsaicin, a TRPV1 Ligand, Suppresses Bone Resorption by Inhibiting the Prostaglandin E Production of Osteoblasts, and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide. ISRN Pharmacol. 2012;2012:439860. doi: 10.5402/2012/439860. Epub 2012 Apr 3.

  • Kobayashi M, Matsumoto C, Hirata M, Tominari T, Inada M, Miyaura C. The correlation between postmenopausal osteoporosis and inflammatory periodontitis regarding bone loss in experimental models. Exp Anim. 2012;61(2):183-187. doi: 10.1538/expanim.61.183.

  • Harada S, Tominari T, Matsumoto C, Hirata M, Takita M, Inada M, Miyaura C. Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFκB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency. J Pharmacol Sci. 2011;115(1):89-93. doi: 10.1254/jphs.10193sc.

  • Hirata M, Kobayashi M, Matsumoto C, Miyaura C, Asakura T, Inada M. Cell Shape and Matrix Production of Fibroblasts Cultured on Fibroin-organized Silk Scaffold with Type-II β-turn Structured (Ala-Gly-Ala-Gly-Ser-Gly)n Sequences. J Health Sci.2010 Aug 13;56(6):738-744. doi: 10.1248/jhs.56.738.

  • Kim J, Kobayashi M, Fukuda M, Ogasawara D, Kobayashi N, Han S, Nakamura C, Inada M, Miyaura C, Ikebukuro K, Sode K. Pyrroloquinoline quinone inhibits the fibrillation of amyloid proteins. Prion. 2010 Jan-Mar;4(1):26-31. doi: 10.4161/pri.4.1.10889. Epub 2010 Jan 4.

  • Hirata M, Kobayashi M, Takita M, Matsumoto C, Miyaura C, Inada M. Hyaluronan inhibits bone resorption by suppressing prostaglandin E synthesis in osteoblasts treated with interleukin-1. Biochem Biophys Res Commun. 2009 Apr 3;381(2):139-143. doi: 10.1016/j.bbrc.2009.01.146. Epub 2009 Jan 29.

  • Hirata M, Inada M, Matsumoto C, Takita M, Ogawa T, Endo Y, Miyaura C. A novel carborane analog, BE360, with a carbon-containing polyhedral boron-cluster is a new selective estrogen receptor modulator for bone. Biochem Biophys Res Commun. 2009 Mar 6;380(2):218-222. doi: 10.1016/j.bbrc.2009.01.033. Epub 2009 Jan 19.

  • Hirata M, Matsumoto C, Takita M, Miyaura C, Inada M. Naringin suppresses osteoclast formation and enhances bone mass in mice. J Health Sci.2009;55(3):463-467. doi: 10.1248/jhs.55.463.

  • Inada M, Tsukamoto K, Hirata M, Takita M, Nagasawa K, Miyaura C. Novel vitamin D3 analogs, 1alpha, 25(OH)2D(3)-26, 23-lactam (DLAMs), antagonize bone resorption via suppressing RANKL expression in osteoblasts. Biochem Biophys Res Commun. 2008 Aug 1;372(3):434-439. doi: 10.1016/j.bbrc.2008.05.041. Epub 2008 May 19.

  • Takita M, Hirata M, Tsukamoto K, Nagasawa K, Miyaura C, Inada M. 1α,25-Dihydroxyvitamin D3-26,23-lactam, a Novel Vitamin D3 Analog, Acts as a Vitamin D3 Antagonist in Human Prostate Cancer Cells. J Health Sci. 2008;54(4):497-502.doi: 10.1248/jhs.54.497.

  • Gutiérrez-Fernández A, Inada M, Balbín M, Fueyo A, Pitiot AS, Astudillo A, Hirose K, Hirata M, Shapiro SD, Noël A, Werb Z, Krane SM, López-Otín C, Puente XS. Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J. 2007 Aug;21(10):2580-91. doi: 10.1096/fj.06-7860com. Epub 2007 Mar 28.

  • Tamura K, Suzuki Y, Matsushita M, Fujii H, Miyaura C, Aizawa S, Kogo H. Prevention of aortic calcification by etidronate in the renal failure rat model. Eur J Pharmacol. 2007 Mar 8;558(1-3):159-66. doi: 10.1016/j.ejphar.2006.12.006. Epub 2006 Dec 29.

  • Takita M, Inada M, Maruyama T, Miyaura C. Prostaglandin E receptor EP4 antagonist suppresses osteolysis due to bone metastasis of mouse malignant melanoma cells. FEBS Lett. 2007 Feb 6;581(3):565-571. doi: 10.1016/j.febslet.2007.01.005. Epub 2007 Jan 16.

  • Takita M, Inada M, Miyaura C. Capsaicin, A Ligand for Vanilloid Receptor-1, Transduces Suppressive Signal for Osteoclast Differentiation in Bone. J Health Sci. 2007;53(2):240-244. doi: 10.1248/jhs.53.240.

  • Matsumoto C, Takita M, Inada M, Maruyama T, Miyaura C. Prostaglandin E Receptor EP4 Antagonist Suppresses Lipopolysaccharide-Induced Osteoclast Formation and Inflammatory Bone Loss. J Health Sci. 2007;53(2):234-239. doi: 10.1248/jhs.53.234.

  • Sugiyama F, Wu J, Fujioka M, Ezaki J, Takeda K, Miyaura C, Ishida T, Yamada K, Ishimi Y. Soybean isoflavones preserve bone mass in hindlimb-unloaded mice. J Bone Miner Metab. 2006;24(6):439-46. doi: 10.1007/s00774-006-0711-2.

  • Inoue K, Mikuni-Takagaki Y, Oikawa K, Itoh T,Inada M, Noguchi T, Park JS, Onodera T, Krane SM, Noda M, Itohara S. A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism. J Biol Chem. 2006 Nov 3;281(44):33814-33824. doi: 10.1074/jbc.M607290200. Epub 2006 Sep 7.

  • Inada M, Matsumoto C, Uematsu S, Akira S, Miyaura C. Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation. J Immunol. 2006 Aug 1;177(3):1879-1885. doi: 10.4049/jimmunol.177.3.1879.

  • Matsumoto C, Inada M, Toda K, Miyaura C. Estrogen and androgen play distinct roles in bone turnover in male mice before and after reaching sexual maturity. Bone. 2006 Feb;38(2):220-226. doi: 10.1016/j.bone.2005.08.019. Epub 2005 Oct 6.

  • Deguchi JO, Aikawa E, Libby P, Vachon JR, Inada M, Krane SM, Whittaker P, Aikawa M. Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation. 2005 Oct 25;112(17):2708-15. doi: 10.1161/CIRCULATIONAHA.105.562041. Epub 2005 Oct 17.

  • Kennedy AM, Inada M, Krane SM, Christie PT, Harding B, López-Otín C, Sánchez LM, Pannett AA, Dearlove A, Hartley C, Byrne MH, Reed AA, Nesbit MA, Whyte MP, Thakker RV. MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO). J Clin Invest. 2005 Oct;115(10):2832-42. doi: 10.1172/JCI22900.

  • Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, López-Otín C, Krane SM.Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17192-7. doi: 10.1073/pnas.0407788101. Epub 2004 Nov 24.

  • Sabeh F, Ota I, Holmbeck K, Birkedal-Hansen H, Soloway P, Balbin M, Lopez-Otin C, Shapiro S, Inada M, Krane S, Allen E, Chung D, Weiss SJ. Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol (IF: 10.54; Q1). 2004 Nov 22;167(4):769-81. doi:10.1083/jcb.200408028.