We are also focusing on production of various useful compounds from CO2 through metabolic engineering techniques such as multi-omics analysis and genome editing (Fig. 3), selecting microalgae with advantageous phenotype from the “Marine Culture Collection”. Some microalgae selected so far are suitable for the production of biofuels and bioactive compounds (Fig. 4). We have achieved the whole genome sequencing and the establishment of transformation method in these microalgae, as well. These fundamental technologies enable us to modify intracellular metabolism, leading to the production of a wide variety of valuable compounds from CO2, such as bioplastic raw materials and pharmaceutical ingredients, which were difficult to produce thus far (Fig. 5).