Tokyo University of Agriculture and Technology Tanaka & Kataoka Lab.
Lifespan Regulation and Aging Mechanisms
Organisms have evolved the ability to adjust their lifespan and regulate aging speed according to their environment and ecology. These regulatory mechanisms are crucial evolutionary strategies that enable organisms to adapt and thrive. By utilizing diverse model organisms, particularly mammals and insects, we can elucidate the molecular mechanisms involved in lifespan regulation and aging.
In this research, we employ multi-omics analyses, including genomics, transcriptomics, and proteomics, to comprehensively study the genes and metabolic pathways that control lifespan and aging. By using insects, which have shorter lifespans than mammals, we can conduct rapid analyses to understand the molecular foundations of aging-related phenomena such as memory decline and changes in biological rhythms. Through these studies, we are advancing basic research aimed at developing new technologies to extend healthy lifespan and prevent aging-related diseases (Fig. 3).
This research aims to understand the evolutionary background of lifespan regulation and aging mechanisms, while exploring practical applications of these findings for the benefit of future society.
