2026年

2. Prodrug design of bispecific antibody masked with interleukin 2 for effectively activating lymphocytes
   Daimei Miura^†, Miyuu Sekine^†, Linko Hirano, Yuki Kato, Masahiro Yasunaga, Izumi Kumagai, Ryutaro Asano^*
   Biochemical Engineering Journal (2026) 233, 110260; doi.org/10.1016/j.bej.2026.110260


3. Convenient and sensitive detection of viable Escherichia coli employing a sequential reaction between antibody-enzyme complexes
   Shogo Izumi, Daimei Miura, Yasukazu Maeda, Koji Sode, Wakako Tsugawa, Kazunori Ikebukuro, Ryutaro Asano^*
   Biosensors and Bioelectronics (2026) 309, 118810; doi.org/10.1016/j.bios.2026.118810


4. Rapid and convenient electrochemical hemoglobin detection in mouse feces employing a DNA aptamer to evaluate the severity of colitis in a mouse model
   Mizuki Nakashima^†, Daimei Miura^†, Erika Komiya, Nanami Watanabe, Kaori Tsukakoshi, Tsutomu Omatsu, Wakako Tsugawa, Koji Sode, Kazunori Ikebukuro, Toshinori Yoshida and Ryutaro Asano^*
   Analytical Methods (2026) 18(19), 3924-3927; doi.org/10.1039/D6AY00278A


5. Protocol:
   Measurement of T Cell Migration by T Cell-Dependent Bispecific Antibody in Cancer Cells and T Cell Cross-Linking
   Rikuto Nakamura, Ryo Tsumura, Takahiro Anzai, Ryutaro Asano and Masahiro Yasunaga^*
   Method in Molecular Biology (2026) 143-149; doi.org/10.1007/978-1-0716-5037-0_10


6. Protocol:
   Visualization of Immunological Synapse Formation by Intercellular Cross-Linking of T Cell-Dependent Bispecific Antibodies Using Fluorescence Microscopy
   Rikuto Nakamura, Ryo Tsumura, Takahiro Anzai, Ryutaro Asano and Masahiro Yasunaga^*
   Method in Molecular Biology (2026) 135-142; doi.org/10.1007/978-1-0716-5037-0_9


7. Protocol:
   Production of Bispecific Antibody Fragments from Fc Fusion
   Ryutaro Asano^*
   Method in Molecular Biology (2026) 99-105; doi.org/10.1007/978-1-0716-5037-0_6


8. Protocol:
   Design and Evaluation of Domain-Rearranged Bispecific Antibody Fragments for Functional Optimization
   Ryutaro Asano^*
   Method in Molecular Biology (2026) 91-97; doi.org/10.1007/978-1-0716-5037-0_5


9. Turning on Protein Function Inhibited by DNA Aptamers Employing a Covalent DNA-Binding Protein
   Takeru Kanazu, Erika Komiya, Daimei Miura, Kaori Tsukakoshi, Kazunori Ikebukuro^*, Tomohiko Yamazaki^* and Ryutaro Asano^*
   ACS Nanoscience Au (2026) 6(2), 201-207; doi.org/10.1021/acsnanoscienceau.5c00143


10. Creation of an Engineered Oxygen-Insensitive L-Glutamate Oxidase for the Application of Electrochemical L-Glutamate Sensors
    Mika Hatada^†, Shouhei Takamatsu^†, Ryutaro Asano, Kazuo Ikebukuro, Wakako Tsugawa and Koji Sode^*
    International Journal of Molecular Sciences (2026) 27(6), 2831; doi.org/10.3390/ijms27062831


11. A Unique Insertion Loop Facilitates Tight NAD+ Binding in Nicotinoprotein: Insights from In Vitro Loop Engineering and In Silico Studies
    Houcheng Xue, Takumi Yanase, Junko Okuda-Shimazaki, Haruka Kawai, Daimei Miura, Ryutaro Asano, Kazunori Ikebukuro, Koji Sode and Wakako Tsugawa^*
    International Journal of Molecular Sciences (2026) 27(5), 2367; doi.org/10.3390/ijms27052367


12. Strategic aptamer evolution for SARS-CoV-2 to enable the detection in human saliva
    Daimei Miura, Wakana Hayashi, Sakura Nashiki, Katsuya Oguchi, Haruka Kawai, Kaori Tsukakoshi, Wakako Tsugawa, Ryutaro Asano^* and Kazunori Ikebukuro^*
    Biosensors and Bioelectronics (2026) 298, 118423; doi.org/10.1016/j.bios.2026.118423


13. Engineering chain-branched bispecific VHH complexes (“Dendrobodies”) using SpyCatcher and SnoopCatcher pairings
    Kota Kurogane, Miyuu Sekine, Ryutaro Asano, Shigekazu Yano and Koki Makabe^*
    Biochemical and Biophysical Research Communications (2026) 806, 153413; doi.org/10.1016/j.bbrc.2026.153413


14. Wash-free electrochemical biosensor for CpG methylation using a quasi-direct electron transfer type enzyme as the labeling enzyme
    Mizuki Tomizawa, Runa Hosaka, Daimei Miura and Kazunori Ikebukuro^*
    Biosensors and Bioelectronics (2026) 295, 118285; doi.org/10.1016/j.bios.2025.118285


15. Review:
    Challenges in realizing therapeutic antibody biosensing
    Madoka Nagata, Ellie Wilson, Kazunori Ikebukuro^* and Koji Sode^*
    Trends in Biotechnology (2026) 44(2), 365-377; doi.org/10.1016/j.tibtech.2025.07.003


16. Competitive-SELEX discovery of DNA aptamers selective for neurofilament light chain in human plasma
    Miyu Matsumoto, Kazunori Ikebukuro^* and Kaori Tsukakoshi^*
    Biochemical and Biophysical Research Communications (2026) 796, 153151; doi.org/10.1016/j.bbrc.2025.153151


17. Detection of Structural Changes in G-Quadruplex-Forming DNA Oligonucleotides via DNA Methylation Based on Luminol Chemiluminescence Catalyzed by Myoglobin
    Shintaro Inaba, Hatuka Kawai, Mizuki Tomizawa, Daimei Muira, Kaori Tsukakoshi and Kazunori Ikebukuro^*
    Biosensors (2026) 16(1), 1; doi.org/10.3390/bios16010001


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