Achievements
Dr. Hori's (A01 Representative) paper was published in Neuroscience Research.
Hori's (A01 Representative) paper was published in Neuroscience Research.
We discovered APP-dependent tau secretion.
Sato H, Kasuga K, Isoo N, Hayashi T, Ikeuchi T, Hori Y#, Tomita T#: Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion, Neuroscience Research, 2023, S0168-0102(23)00068-8
Dr. Tsukakoshi's (C01 Representative) paper was published in Journal of Materials Chemistry B.
Dr. Tsukakoshi's (C01 Representative) paper was published in Journal of Materials Chemistry B. Dr. Tsukakoshi contributed to the identification of the amyloid fibrillogenic potential of α-S1-casein, which is involved in canine mammary gland amyloidosis, by recombinant protein preparation and in vitro amyloid fibrillation assay.
Murakami T, Kaku T, Tsukakoshi K, et al. Identification of novel amyloidosis in dogs: α-S1-casein acquires amyloidogenicity in mammary tumor by overexpression and N-terminal truncation. Veterinary Pathology. 2023 in press
Dr. Hashimoto's (B01 Representative) paper was published in Scienctific Reports.
Dr. Hashimoto's (B01 Representative) paper was published in Scienctific Reports. Dr. Hashimoto found that oxidative stress caused by glutathione depletion leads to neurodegeneration via inflammatory cell death.
Hashimoto S, Matsuba Y, Takahashi M, et al. Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation. Sci Rep 13, 1109 (2023).
A review article by Dr. Hori (A01 Representative) was published in Folia Pharmacol. Jpn.
A review article by Hori (Representative of A01) was published in Folia Pharmacol. Jpn. It summarizes the identification of regulators of Aβ production by genome-wide screening using CRISPR/Cas9.
Tomizawa I, Chiu YW, Hori Y#, Tomita T#: Identification of novel regulators involved in AD pathogenesis using the CRISPR-Cas9 system. Folia Pharmacol. Jpn., 158, 21-25
A paper for which Dr. Tsukakoshi (C01 Representative) is the corresponding author has been published in Int. J. Mol. Sci.
A paper for which Dr. Tsukakoshi (C01 Representative) is the corresponding author has been published in Int. J. Mol. Sci. Dr. Tsukakoshi and co-authors developed a new ligand specific for amyloid-β oligomers, which are toxic in the brains of patients with Alzheimer's disease-type dementia.
Tsukakoshi, K., Kubo, R. & Ikebukuro, K. Development of Alkaline Phosphatase-Fused Mouse Prion Protein and Its Application in Toxic Aβ Oligomer Detection. Int J Mol Sci 23(23), 14588
A paper by Dr. Tsukakoshi (C01 Representative) has been published in Journal of Materials Chemistry B.
Dr. Tsukakoshi was in charge of research on structural modification of hemin-binding DNA aptamers that function as DNAzyme.
Renzo A Fenati, Zifei Chen, Yasuko Yamagishi, Kaori Tsukakoshi, Kazunori Ikebukuoro, Anjay Manian, Salvy P Russo, Tomohiko Yamazaki, Amanda V Ellis Enhancement of DNAzymatic activity using iterative in silico maturation. Journal of Materials Chemistry B Advance Article (2022)
Commentary by Hori (A01 Representative) was published in Neuroscience Insight.
Commentary by Hori (A01 Representative) was published in Neuroscience Insight. It is a commentary on Ozawa S, Hori Y et al, Brain, 2021.
Hori Y#, Sohma Y, Kanai M, Tomita T#: Promotion in the clearance of aggregated Aβ in vivo using amyloid selective photo-oxygenation technology, Neuroscience Insight, commentary, 2022; 17:26331055221126179.
Dr. Tsukakoshi's (C01 Representative) paper was published in Journal of Molecular Liquids.
Dr. Tsukakoshi was in charge of analytical research on the binding ability and structure of DNA aptamers.
Kyoko Fujita, Takuya Honda, Kaori Tsukakoshi, Hiroyuki Ohno, Kazunori Ikebukuro,
The state of water molecules induces changes in the topologies and interactions of G-quadruplex DNA aptamers in hydrated ionic liquid. Journal of Molecular Liquids 366, 120175 (2022)
Dr. Yamagishi's (C01) paper was published in Biosens. Bioelectron.
Using AFM and antibody-modified nanoneedles, we have succeeded in mechanistically detecting transcription-related factors that bind to intermediate diameter filaments in living cells.
Yamagishi, A., Mizusawa, M., Uchida, K., Iijima, M., Kuroda, S., Fukazawa, K., Ishihara, K., Nakamura, C.
Mechanical detection of interactions between proteins related to intermediate filament and transcriptional regulation in living cells, Biosens. Bioelectron. 216, 114603 (2022)
https://www.sciencedirect.com/science/article/pii/S0956566322006431?via%3Dihub
Dr. Tsukakoshi's (C01 Representative) paper was published in ACS chemical biology.
Dr. Tsukakoshi was in charge of the analytical study of the guanine quadruplex structure by combining CD spectroscopic measurements and principal component analysis.
Tu, A.T.T., Hoshi, K., Ma, Y., Oyama, T., Suzuki, S., Tsukakoshi, K., Nagasawa, K., Ikebukuro, K. & Yamazaki, T. Effects of G-Quadruplex Ligands on the Topology, Stability, and Immunostimulatory Properties of G-Quadruplex-Based CpG Oligodeoxynucleotides. ACS Chem Biol 17, 1703-1713 (2022)
Dr. Hashimoto's (B01 Representative) paper was published in J. Biochem.
We identified a novel tau-binding protein, PRMT8, and found that PRMT8 contributes to vacuolar degeneration.
Ishii, A. Matsuba, Y. Mihira, N. Kamano, N. Saito, T. Muramatsu, S. Yokosuka, M. Saido, TC. & Hashimoto, S.
Tau-binding protein PRMT8 facilitates vacuole degeneration in the brain. J. Biochem. mvac058, (2022)
https://academic.oup.com/jb/advance-article/doi/10.1093/jb/mvac058/6639910?login=true
A review article by Hori (A01 Representative) was published in Front. Aging Neurosci.
A review article by Hori (A01 Representative) was published in Front. Aging Neurosci.
It summarizes his research on the photo-oxygenation method, which he originally developed for the treatment of AD.
Tomizawa I, Nakagawa H, Sohma Y, Kanai M, Hori Y*, and Tomita T*; Photo-oxygenation as a new therapeutic strategy for neurodegenerative proteinopathies by enhancing the clearance of amyloid proteins, Front. Aging Neurosci. 14:945017 (2022)
https://www.frontiersin.org/articles/10.3389/fnagi.2022.945017/full
Dr. Tsukakoshi's (C01 Representative) paper was published in Int. J. Mol. Sci.
Dr. Tsukakoshi's contribution to this study centered on the analysis of the imotif structure, which is also expected to serve as the backbone structure of aptamers.
Oshikawa, D., Inaba, S., Kitagawa, Y., Tsukakoshi, K. & Ikebukuro, K. CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands. Int J Mol Sci 23 (2022)
Dr. Hashimoto's (B01 Representative) paper was published in Sci. Adv.
Contributed to the development of mouse models of Alzheimer's disease, which are useful for the investigation of β-secretase inhibitors.
Watamura, N. Sato, K. Shiihashi, G. Iwasaki, A. Kamano, N. Takahashi, M. Sekiguchi, M. Mihira, N. Fujioka, R. Nagata, K. Hashimoto, S. Saito, T. Ohshima, T. Saido, TC. & Sasaguri, H.
An isogenic panel of App knock-in mouse models: profiling β-secretase inhibition and endosomal abnormalities” Sci Adv 8 (23) eabm6155 (2022)