Achievements
Co-first authored by Dr. Tsukakoshi (C01 Representative) paper was published in PNAS Nexus.
Co-first authored by Dr. Tsukakoshi (C01 Representative) paper was published in PNAS Nexus.
We succeeded in real-time monitoring of oligomer formation of amyloid β on lipid bilayer membranes using channel current measurement technology.
Yuri Numaguchi†, Kaori Tsukakoshi†, Nanami Takeuchi, Yuki Suzuki, Kazunori Ikebukuro, Ryuji Kawano. Development of Alkaline Phosphatase-Fused Mouse Prion Protein and Its Application in Toxic Aβ Oligomer Detection. PNAS Nexus, pgad437, Accepted (†These authors are equally contributed.)
https://academic.oup.com/pnasnexus/advance-article/doi/10.1093/pnasnexus/pgad437/7473450
Dr. Hori's (A01 Representative) paper was published in FASEB Journal.
Dr. Hori's (A01 Representative) paper was published in FASEB Journal.
We established a photooxygenation method for α-synuclein and clarified that oxygenation of synuclein His residues is important for its effectiveness.
Nakamura R, Tomizawa I, Iwai A, Ikeda T, Hirayama K, Chiu YW, Suzuki T, Tarutani A, Mano T, Iwata A, Toda T, Sohma Y, Kanai M, Hori Y#, Tomita T#: Photo-oxygenation of histidine residue inhibits α-synuclein aggregation, FASEB J., 2023, 37(12): e23311.
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202301533R
Dr. Tsukakoshi's (C01 Representative) paper was published in Biosens. Bioelectron.
Dr. Tsukakoshi's (C01 Representative) paper was published in Biosens. Bioelectron.
This is a report on the development of a molecular detection system that combines aptamers and magnetic nanoparticles.
Rokutani, S., Hiraka, K., Saitoh, H., Saito, T., Nonaka, Y., Ueno, K., Tsukakoshi, K., Ohnishi, N. and Ikebukuro, K. (2024) Aptamer-enhanced particle aggregation inhibition assay for simple homogeneous protein detection using DNA aptamer and thermo-responsive magnetic nanoparticles. Biosens Bioelectron, 245, 115827.
https://www.sciencedirect.com/science/article/pii/S0956566323007698
Dr. Yamagishi's (C01) paper was published in Biochemical and Biophysical Research Communications.
Dr. Yamagishi's (C01) paper was published in Biochemical and Biophysical Research Communications.
We succeeded in improving genome editing efficiency in plants by modifying Cas9 proteins on microneedle arrays via polymers.
Anchu Viswan, Chiaki Yoshikawa, Ayana Yamagishi Yuichi Furuhata, Yoshio Kato, Tomohiko Yamazaki, Chikashi Nakamura, Efficient genome editing by controlled release of Cas9 ribonucleoprotein in plant cytosol using polymer-modified microneedle array. Biochem. Biophys. Res. Commun., 2023
https://www.sciencedirect.com/science/article/pii/S0006291X23012731
Dr. Tsukakoshi's (C01 Representative) paper was published in Analytical Sciences.
Dr. Tsukakoshi's (C01 Representative) paper was published in Analytical Sciences.
This is a report on antibody drug analysis using aptamers as affinity ligands.
Kenichiro Todoroki, Daichi Hamada, Tomohiro Yamada, Taro Saito, Yutaka Shimizu, Eiji Sugiyama, Hajime Mizuno, Hideki Hayashi, Kaori Tsukakoshi & Kazunori Ikebukuro, Development of a liquid chromatography-based versatile bioanalysis for bevacizumab based on pretreatment combining aptamer affinity purification and centrifugal ultrafiltration concentration Anal Sci., 2023 in press
https://link.springer.com/article/10.1007/s44211-023-00417-2
A review article by Dr. Hashimoto (B01 Representative) was published in Translational and Regulatory Science.
A review article by Dr. Hashimoto (B01 Representative) was published in Translational and Regulatory Science.
This report summarizes the development of mouse models of Alzheimer's disease and research using these models.
Hashimoto S and Saido TC, Generation of sophisticated Alzheimer’s disease mouse models and research advances utilizing them, Translat Regulat Sci 5(2) 40-52 (2023)
Dr. Hori's (A01 Representative) paper was published in iScience.
Hori's (A01 Representative) paper was published in iScience.
We discovered the effect of INPP5D on microglial function.
Iguchi A, Takatori S, Kimura S, Muneto H, Wang K, Etani H, Ito G, Sato H, Hori Y, Sasaki J, Saito T, Saido CT, Ikezu T, Takai T, Sasaki T, Tomita T: INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model, iScience, 2023, 13;26(4):106375.