Creation of Aptameric biology

About Aptameric Biology

This research area aims to create "aptameric biology," a novel approach to elucidate the biological function of proteins. We propose to elucidate living systems through pathway-specific and flexible control without genetic modification by introducing aptamers that regulate protein activity into model animals.

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2023.12.14 Co-first authored by Dr. Tsukakoshi (C01 Representative) paper was published in PNAS Nexus.
2023.11.14 Dr. Hori's (A01 Representative) paper was published in FASEB Journal.
2023.11.10 Dr. Tsukakoshi's (C01 Representative) paper was published in Biosens. Bioelectron.
2023.11.07 Dr. Yamagishi's (C01) paper was published in Biochemical and Biophysical Research Communications.
2023.10.17 At the 13th CSJ Chemistry Festa 2023 of the Autumn Events of the Chemical Society of Japan, joint special project “Developing technology to understand, manipulate, and see the functions of biomolecules within cells” will be held on “Multiple Response Genomes”, “Aptamer Biology” and “Innovative Raman” was hosted.
2023.09.03 Dr. Tsukakoshi's (C01 Representative) paper was published in Analytical Sciences.
2023.08.31 The second area meeting was held.
2023.08.20 A review article by Dr. Hashimoto (B01 Representative) was published in Translational and Regulatory Science.
2023.08.01 The Chemical Society of Japan (CSJ) will sponsor a joint special program "Multidimensional Responsive Genomics," "Aptamer Biology," and "Innovative Raman: Developing Technologies to Know, Manipulate, and See the Functions of Biomolecules in the Cell" at the 13th CSJ Chemistry Festa 2023, Fall Program of the CSJ. (Tuesday, October 17, 2023, 13:30-17:30)
2023.04.07 Dr. Hori's (A01 Representative) paper was published in iScience.
2023.03.24 Dr. Hori's (A01 Representative) paper was published in Neuroscience Research.
2023.01.21 Dr. Tsukakoshi's (C01 Representative) paper was published in Journal of Materials Chemistry B.
2023.01.20 Dr. Hashimoto's (B01 Representative) paper was published in Scienctific Reports.
2023.01.06 A review article by Dr. Hori (A01 Representative) was published in Folia Pharmacol. Jpn.
2023.01.01 Dr. Hashimoto (B01 Representative) has transferred from RIKEN to the Medical Innovation Research Center, Shiga University of Medical Science.
We will continue to push forward with research in our new location.
2022.11.27 Symposium "Cutting Edge of Aptamer Application in Neurodegenerative Disease Research" was held at the 41st Annual Meeting of the Japan Society for Dementia Research and the 37th Annual Meeting of the Japanese Psychogeriatric Society.
2022.11.23 A paper for which Dr. Tsukakoshi (C01 Representative) is the corresponding author has been published in Int. J. Mol. Sci.
2022.10.28 The first area meeting was held.
2022.10.21 A paper by Dr. Tsukakoshi (C01 Representative) has been published in Journal of Materials Chemistry B.
2022.09.28 Commentary by Hori (A01 Representative) was published in Neuroscience Insight.
2022.09.27 Dr. Tsukakoshi's (C01 Representative) paper was published in Journal of Molecular Liquids.
2022.09.26 Symposium "Cutting Edge of Aptamer Application in Neurodegenerative Disease Research" will be held at the 41st Annual Meeting of the Japanese Dementia Society and the 37th Annual Meeting of the Japanese Association for Geriatric Psychiatry.
2022.09.02 An interview with Dr. Tsukakoshi, the area Representative, was posted on the website of the TUAT-OPERA consortium project.
[Interview with OPERA Researcher] A Research Path Linked by Enthusiasm - Empowering the Third Choice, Not a Two-Way Choice.[JP]
2022.08.24 The website for "Creation of Aptameric biology" is now available.
2022.08.06 Dr. Yamagishi's (C01) paper was published in Biosens. Bioelectron.
2022.07.15 Dr. Tsukakoshi's (C01 Representative) paper was published in ACS chemical biology.
2022.07.11 Dr. Hashimoto's (B01 Representative) paper was published in J. Biochem.
2022.06.23 A review article by Hori (A01 Representative) was published in Front. Aging Neurosci.
2022.06.09 Dr. Tsukakoshi's (C01 Representative) paper was published in Int. J. Mol. Sci.
2022.06.08 Dr. Hashimoto's (B01 Representative) paper was published in Sci. Adv.
2022.05.31 Kickoff meeting was held (Zoom, not open to the public).
2022.05.20 This area has been adopted as a Grant-in-Aid for Transformative Research Areas (B).

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Planned Research

Research Content
A01

Elucidation and regulation of Aβ homeostasis using aptameric biology
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Research Content
B01

Elucidation of protection mechanisms against neuronal cell death under neuroinflammation by Aptameric biology
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Research Content
C01

Development of mouse model to investigate brain homeostasis using protein-function-enhancing aptamers
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