About Aptameric Biology
To elucidate the functions of proteins in biological phenomena, new approaches are needed, such as gene modification techniques using CRISPR-Cas9, gene knockdown using siRNA, and chemical genetic approaches using artificial ligands. These techniques have contributed to the elucidation of the biological functions of proteins.
Our research in this area aims to create a novel biological research field, "aptamer biology," This challenging research aims to revolutionize life science research by applying aptamer-based protein activity enhancing methods. By introducing aptamers that enhance the function of proteins involved in brain homeostasis into the mouse brain, we will conduct pathway-specific research to elucidate the life system that controls the homeostasis mechanism in the brain. We have named this type of biological research based on protein manipulation by aptamers "aptamer biology."
Area Leader　Dr. Kaori Tsukakoshi
Graduate School of Engineering, Tokyo University of Agriculture and Technology
