Disease model cells of diabetes.Regenerative cell engineering. ES cells.Single-cell gene engineering. Femtoinjection.Food safety control and regulatory science.
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In our lab, we drive towards the exploitation and elucidation of the characteristics, role and molecular traits of novel/uncultivable environmental microorganisms using molecular biology based approaches.
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Structural and functional analysis of proteins at atomic/molecular level using recombinant DNA technologies, NMR, X-ray crystallography, and computational simulation. Biophysical studies of protein aggregation.
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i) Structural analysis of silk fibroins.
ii) Development of the medical implantation devices such as artificial cardiac valves and cardiovascular patches based on the silk fibroin.
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Molecular pathological investigation using gene targeted mice and disease models on mice.
lnvestigations of refractory diseases for clinical drug development are employed for lifestyle-related diseases such as Cancer,Osteoporosis, Rheumatoid Arthritis and Periodonititis. Functional analysis of molecular biochemistry using mammalian cell to individuals are promoted research.
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Development of novel techniques for organelle imaging and their application to mitochondrial study. Cell death, Ca2+ signaling and generation of reactive oxygen species are mainly focused.
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Molecular biological and biochemical studies on the enzymes involved in plant secondary metabolisms. Molecular biological analysis of the genes based on the functin of the proteins related to salt-tolerance phenotype of the halophyte.
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Biomolecular engineering for the development of 1) novel enzymes for the diagnostic application,and 2) novel proteins for the application in the synthetic biology. Development of novel biodevices for the creation of theranostic platforms and environmental monitoring systems.
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Artificial protein design based mainly on antibody molecules and their detailed functional analyses for development of next-generation biologicals and biosensors.
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I focus on the interaction between nucleic acids and proteins and apply it to develop biosensing system for new biomarkers or epigenetic modification. I am also engaged in the evolutionary molecular engineering research to improve function of nucleic acids and proteins to adjust those to those applications using computer.
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The goal of my research is to establish a system that uses biological nanopores for single-molecule detection. Channel membrane proteins have nanochannels around 1 nm in size. These biological nanopores are capable of detecting and electrically recognize even single molecules with a high signal-to-noise ratio. However, the channel size is limited by the inherent protein structure. I plan to develop artificial nanochannels such as synthetic nanopores or polypeptides combined with biomaterials (proteins and lipid bilayers) on the basis of MEMS technology for novel nanopore sensing.
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We conduct research on the production of valuable substances—such as biofuels, cosmetics, and chemical products—from carbon dioxide by harnessing the diverse biological functions of microalgae. In addition, we develop measurement devices for medical diagnostics and environmental applications by leveraging image informatics technologies.
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We study biological diversity and mechanisms of environmental adaptation through multi-omics analyses and behavior analysis using deep learning. In particular, we aim to elucidate the evolutionary mechanisms underlying the unique functions of insects and diatoms, and to apply these insights to the creation of novel bioresources.
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Our research also focuses on elucidating the formation mechanisms of hard biological tissues, such as biominerals, and on developing new materials and material synthesis processes based on these mechanisms. We pay special attention to nanoscale magnetic particles produced by magnetotactic bacteria and to the beetle cuticle, which exhibits diverse structures and mechanical properties, and we investigate these systems using molecular biological approaches.
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We promote medical–engineering and industry–academia collaborations through the development of bioanalytical devices and the creation of nanomaterials using microorganisms. In particular, we are developing technologies and devices for the genetic analysis of rare circulating cancer cells in the blood of cancer patients, with the aim of identifying new cancer diagnostic markers and therapeutic targets.
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Bioelectrochemistry and Raman spectroscopy of metalloproteins and construction of biofuel cells.
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Self-organization of liquid crystals provides well-ordered and highly-defined nanostructures, and therefore they have attracted increasing attention in the field of the development of next-generation soft materials. Among various liquid-crystalline materials, we have focused on bicontinuous cubic liquid crystals with expecting their three-dimensionally continuous nanostructures. Bicontinuous cubic structures are composed of three-dimensionally interwoven nanochannel domains and a surrounding sheath domain. Owing to their continuous structures, their application for nanostructured materials are now strongly expected.
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Total synthesis of biologically active natural products. Development of organocatalyst.
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Design and synthesis of functional small molecules controlling live cells and nucleic acids–protein interactions based on bioorthogonal reactions. Biological evaluation of the synthesized small molecules to apply to regenerative medicine and drug discovery.
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Development of novel chemical tools to study biological functions of glycolipids and natural products.
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We examine role of cilia in our body. Cilia are nanomachine motor devices that protrude from cell surface and play important role on transport of fluid in airway, brain, and oviduct. Using knockout mouse, electron microscopy, and protein engineering, we address molecular basis of motility and mechanical property of cilia: How cilia move or how cilia acquire their stiffness and integrity.

Structure and function of molecular chaperones. Genetic analysis systems for SNP genotyping and bioremediation. Structure and function of metalloenzymes. Protein X-ray crystallography.
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Our laboratory performs the research of systems biology through the development of mass spectrometry omics techniques that illuminate the diversity of metabolites from plant, human, and the associated microbiome.
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Computationally-driven enzyme engineering enables the sustainable biosynthesis of virtually any desired chemical product. Therefore, we are developing computational approaches for the discovery and engineering of specialized enzymes that can extend metabolic pathways to produce valuable medicinal compounds.
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I study theoretical linguistics.
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Cell engineering based on nanotechnology aiming to use iPS cells or somatic stem cells practically for the regenerative medicine. Genome engineering based on high-throughput genome analysis aiming to make fine products from the gene resources of Aspergillus oryzae used for Japanese traditional fermentation industries or the related species. Website