2026
Kamoshita, S., Sakurai, K.*
“Harnessing Collective Electrophilic Reactivity on Gold-Nanoparticles toward Versatile Target Identification”
ChemistryEurope, 2026, 4 (7), e70328.
Fu, J., Kamiya, K., Kitamura, K., Kawahara, R., Shihoya, W., Nureki, O., Hosoya, H., Nakagawa, R., Mashima, T., Itoh, H.*, Inoue, M.*, Sakurai, K.*
“Photoaffinity Labeling Strategy Reveals Tetraspanin CD9 as a Transient Target of Anticancer Yaku'amide B”
J. Am. Chem. Soc., 2026, 148 (3), 2985–2994.
Kamoshita, S., Sakurai, K.* (2026).
“Multivalent Probes for Exploring Carbohydrate Binding Proteins.”
In: Toshima, K., Fujimoto, Y. (eds) Chemical Biology of Carbohydrates. Springer, Singapore.
2025
Khine, M., Isogai N., Takeshita, T. Sakurai, K.*
“Effect of linker length on the function of biotinylated OSW-1 probes”
ChemBioChem 2025, 26, e202400923. An invited article.
Nakamura H., Ito Y., Kandeel M., Sakurai K., Oh-hashi K.*
“Analysis of OSW-1-induced stress responses in HT-29 cells”
BPB Rep. 2025, 8, 1-8.
2024
Sasaki,K., Adachi,T., Morishita,F., Toide,M., Watanabe,Y., Tajima Sakurai,H., Wakabayashi,S., Kusumi,S., Yamaji,T., Sakurai,K., Koga,D., Hanada,K., Yohda,M., Yoshida,H.*
“Dysregulation of PI4P in the trans Golgi regions activates the mammalian Golgi stress response.”
J. Biol. Chem. 2024, 301, 108075.
Tsuruno, A., Kamoshita, S., Hosoya, S., Sakurai, K.*
“Dichlorotriazine-based multivalent probe for selective affinity labeling of carbohydrate-binding proteins.”
Org. Biomol. Chem. 2024, 22, 7659-7663. An invited article.
Koga, S., Miyahara, T., Nishizaki, Y., Tamura, K., Okamoto, E., Kawagishi, H., Sakurai, K., Kaneko, Y., Kumakubo, R., Tanaka, T., Ozeki, Y., Sasaki, N.*
“Anthocyanin glucosylation mediated by a glycoside hydrolase family 3 protein in purple carrot.”
Plant J. 2024, 119, 1816–1829.
2023
Oh-hashi, K.*, Nakamura, N., Ogawa, H., Kandeel, M, Hirata, Y., Sakurai, K.
“Elucidation of OSW1-induced stress responses in Neuro2a cells.”
Int. J. Mol. Sci. 2023, 24, 5787.
Khine, M., Sakurai, K.*
“Golgi-targeting anticancer natural products.”
Cancers 2023, 15, 2086.
An invited article for a special themed issue.
An invited article for a special themed issue.
Fridman, M.*, Sakurai, K.*
“Deciphering the biological activities of antifungal drugs with chemical probes.”
Angew. Chem. Int. Ed. 2023, 62, e202211927.
An invited Minireview article.
An invited Minireview article.
Sakurai, K.*
“Chemical probe-based approach to discovery of target proteins of natural products.”
J. Soc. Jpn. Wom. Sci. 2023, 23, 22-30.
An invited review article.
An invited review article.
2022
Kamoshita, S., Suto, N., Sakurai, K.
“Reactivity analysis of new multivalent electrophilic probes for affinity labeling of carbohydrate binding proteins.”
ChemBioChem 2022, 23, e202100388.
An invited article for a Special Collection in collaboration with the Asian Chemical Biology Initiative (ACBI).
2021
Suto, N., Kamoshita, S., Hosoya, S., Sakurai K.*
“Exploration of the reactivity of multivalent electrophiles for affinity labeling: sulfonyl fluoride as a highly efficient and selective label.”
Angew. Chem. Int. Ed. 2021, 60, 17080-17087.
Mori, K., Sakurai, K.,
“Clickable gold-nanoparticles as generic probe precure for facile photoaffinity labeling application.”
Org. Biomol. Chem. 2021, 19, 1268-1273.
2020
Malabed, R., Hanashima, S.*, Murata, M.*, Sakurai, K.
“Interactions of OSW-1 with lipid bilayers in comparison with digitonin and soyasaponin”
Langmuir 2020, 36 (13), 3600–3610.
Fukaya, K., Urabe, D.,* Hiraizumi, M., Noguchi, K., Matsumoto, T., Sakurai, K.*
“Computational and experimental analysis on the conformational preferences of anticancer saponin OSW-1”
J. Org. Chem. 2020, 85 (2), 339–344.
Mao, J., Itoh, H., Sakurai, K., Inoue, M.,
“Phospholipid-dependent functions of a macrocyclic analogue of the ion-channel-forming antibiotic gramicidin A.”
Chem. Pharm. Bull. 2020, 68, 173-178.
2019
Narita, S., Kobayashi, N., Mori, K., Sakurai, K.*
“Clickable gold nanoparticles for streamlining capture, enrichment and release of alkyne-labelled proteins.”
Bioorg. Med. Chem. Lett. 2019, 29, 126768.
Komatsu, R., Sakurai, K.*
“Development of chemical probes for functional analysis of anticancer saponin OSW-1.”
Chem. Rec. 2019, 19, 2362-2369.
An invited review article.
Kimura, M., Sasaki, K., Fukutani, Y., Yoshida, H., Ohsawa, I., Yohda, M., Sakurai, K.*
“Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.”
Bioorg. Med. Chem. Lett. 2019, 29, 1732-1736.
2018
Kitamura, K., Itoh, H., Sakurai, K., Dan, S., Inoue, M.*
“Target identification of Yaku’amide B and its two distinct activities against mitochondrial F0F1-ATP synthase”
J. Am. Chem. Soc. 2018, 140, 12189-12199.
Sakurai, K.*, Kato, A., Adachi, K.
“Design and synthesis of small molecule-conjugated photoaffinity nanoprobes for a streamlined analysis of binding proteins”
Bioorg. Med. Chem. Lett. 2018, 28, 3227-3230.
Komatsu, R., Yamaguchi, T., Kobayashi, N., Ozeki, Y., Sakurai, K.*
“Synthesis of alkyne-tagged and biotin-tagged Sortin1 as novel photoaffinity probes”
Bioorg. Med. Chem. Lett. 2018, 28, 1562-1565.
Sakurai, K.*
“A peptide-glycolipid interaction probed by retroinverso peptide analogues”
Chem. Pharm. Bull. 2018, 66, 45-50. (An invited article)
2017
Malabed, R., Hanashima, S., Murata, M.,* Sakurai, K.
“Sterol-recognition ability and membrane-disrupting activity of Ornithogalum saponin OSW-1 and usual 3-O-glycosyl saponins”
Biochim. Biophys. Acta 2017, 1859, 2516-2525.
Hiraizumi, M., Komatsu, R., Shibata, T., Ohta, Y., Sakurai, K.*
“Dissecting the structural basis for the intracellular delivery of OSW-1 by fluorescent probes”
Org. Biomol. Chem. 2017, 17, 3568-3570.
Sakurai, K.*, Hiraizumi, M., Isogai, N., Komatsu, R., Shibata, T., Ohta, Y.
“Synthesis of a fluorescent photoaffinity probe of OSW-1 by site-selective acylation of an inactive congener and biological evaluation”
Chem. Commun. 2017, 53, 517-520.
An invited article in a themed issue of “Site-selective molecular transformations.”
2016
Sakurai, K.*, Yamaguchi, T., Mizuno, S.
“Design and synthesis of fluorescent glycolipid photoaffinity probes and their photoreactivity”
Bioorg. Med. Chem. Lett. 2016, 26, 5110-5115.
Yamada, R., Hiraizumi, M., Narita, S., Sakurai, K.*
“Two-step synthesis of a clickable photoaffinity probe from an anticancer saponin OSW-1 and its photochemical reactivity”
Asian J. Org. Chem. 2016, 5, 330–334.
Sakurai, K.*, Hatai, Y., Okada, A.
“Gold nanoparticle-based multivalent carbohydrate probes: selective photoaffinity labeling of carbohydrate-binding proteins”
Chem. Sci. 2016, 7, 702-706.
2015
Sakurai, K.*, Ozawa, S., Yamaguchi, T.
“Photoaffinity labeling studies of the carbohydrate-binding proteins with different affinities”
Bioorg. Med. Chem. 2015, 23, 5319–5325.
Sakurai, K.*, Yasui, T., Mizuno, S.
“Comparative analysis of diazirine-based photoaffinity probes on their reactivity toward a carbohydrate binding protein”
Asian J. Org. Chem. 2015, 4, 724–728.
Sakurai, K.*
“Photoaffinity probes for identification of carbohydrate-binding proteins”
Asian J. Org. Chem. 2015, 4, 116–126.
An invited review article.
Sakurai, K.*
“Photoaffinity labeling approaches toward identification of carbohydrate-lectin interactions”
Trends Glycosci. Glycotech. 2015, 27, 1–12.
2014
Sakurai, K.*, Takeshita, T., Hiraizumi, M., Yamada, R.
“Synthesis of OSW-1 derivatives by site-selective acylation and their biological evaluation”
Org. Lett. 2014, 16 (24), 6318–6321.
Sakurai, K.*, Ozawa, S., Yamada, R., Yasui, T., Mizuno, S.
“Comparison of the reactivity of carbohydrate photoaffinity probes with different photoreactive groups”
ChemBioChem 2014, 15 (10), 1399–1403.
Yamada, R., Takeshita, T., Hiraizumi, M., Shinohe, D., Ohta, Y., Sakurai, K.*
“Fluorescent analog of OSW-1 and its cellular localization”
Bioorg. Med. Chem. Lett. 2014, 24 (8), 1839–1842.
2013
櫻井香里 「フォトアフィニティープローブシステムを用いた生物活性分子―タンパク質相互作用解析へのアプローチ」 生命化学研究レター No.41 (2013 February) 9-13.
Sakurai, K.*, Yamada, R., Okada, A., Tawa M., Ozawa, S., Inoue, M.
“Selective fluorescence detection of small-molecule-binding proteins by using a dual photoaffinity labeling system.”
ChemBioChem 2013, 14, 421-425.
2012
Sakurai, K.*, Tawa, M., Okada, A., Yamada, R., Sato, N., Inahara, M., Inoue, M.
“Active/inactive dual-probe system for selective photoaffinity labeling of small molecule-binding proteins”
Chem. Asian J. 2012, 7, 1567–1571.
2010
Kleiner, R., Dumelin, C., Tiu, G., Sakurai, K., Liu, D. R.
“In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors.”
J. Am. Chem. Soc. 2010, 132, 11779–11791.
Sakurai, K., Kahne, D.
“Design and synthesis of functionalized trisaccharides as p53-peptide mimics.”
Tetrahedron Lett. 2010, 51, 3724-3727.
Sakurai, K.*, Noguchi, K., Nishibe, K.
“3-N-(2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-yl)-1,5-bis(4-methoxyphenyl)biuret.”
Acta Cryst. 2010, E66, o655.
Sakurai, K.*, Fukumoto, T., Noguchi, K., Sato, N., Asaka, H., Moriyama, M., Yohda, M.
“Three dimensional structures of OSW-1 and its congener.”
Org. Lett. 2010, 12, 5732–5735.
2008
Sakurai, K.*, Liu, D. R.
“DNA-Templated Organic Synthesis (DTS): A novel approach to the discovery of functional small molecules based on Nature’s evolutionary principles”
J. Synth. Org. Chem. Jpn. 2008, 66 (6), 590–604.
An invited review article.
2006
Sakurai, K., Schubert, C., Kahne, D.
“Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2”
J. Am. Chem. Soc. 2006, 128 (34), 11000–11001.
2005
Sakurai, K., Snyder, T. M., Liu, D. R.
“DNA-templated functional group transformations enable sequence-programmed synthesis using small molecule reagents”
J. Am. Chem. Soc. 2005, 127 (6), 1660–1661.
2004
Kanan, M. W., Rozenman, M. M., Sakurai, K., Snyder, T. M., Liu, D. R.
“Reaction discovery enabled by DNA-templated synthesis and in vitro selection”
Nature 2004, 431, 545–549.
Sakurai, K., Chung, H. S., Kahne, D.
“Use of a Retroinverso p53 Peptide as an Inhibitor of MDM2”
J. Am. Chem. Soc. 2004, 126 (50), 16288–16289.
1999
Gildersleeve, J., Smith, A., Sakurai, K., Raghavan, S., Kahne, D.
“Scavenging Byproducts in the Sulfoxide Glycosylation Reaction: Application to the Synthesis of Ciclamycin 0”
J. Am. Chem. Soc. 1999, 121, 6176-6182.