New preprint
We have published a new preprint.
PIWI-interacting RNAs (piRNAs) play a crucial role in suppressing transposable elements (TEs) within genes. In many organisms, piRNAs are generated through a complex process known as the ping-pong pathway; however, the significance of this process and its impact on piRNA types were not well understood. By comparing two silkworm cell lines, we discovered that the composition of piRNAs varies significantly. This variation is linked to the efficient production of piRNAs and is thought to result from competition within the ping-pong pathway. This competition also helps piRNAs avoid harmful mismatches.
In short, we found that the piRNA system is highly flexible and adaptive, autonomously optimizing itself to counter various TE sequences.