Publications



[180] Synthetic Chemical Probes That Dissect Vitamin D Activities


 


Akiko Nagata, Yusuke Akagi, Lisa Asano, Kenjiro Kotake, Fumihiro Kawagoe, Aileen Mendoza, Shadi Sedghi Masoud, Kosuke Usuda, Koji Yasui, Yasushi Takemoto, Atsushi Kittaka, Kazuo Nagasawa, Motonari Uesugi
ACS Chem. Biol. 2019, acceptedDOI:10.1021/acschembio.9b00718


[179] Introduction of Fluorine Atoms to Vitamin D3 Side-Chain and Synthesis of 24,24-Difluoro-25-hydroxyvitamin D3


 


Fumihiro Kawagoe, Sayuri Mototani, Kaori Yasuda, Kazuo Nagasawa, Motonari Uesugi, Toshiyuki Sakaki, Atsushi Kittaka
J. Steroid Biochem. Mol. Biol. 2019, acceptedDOI:10.1016/j.jsbmb.2019.105477


[178] Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase


 


Parastoo Maleki, Golam Mustafa, Prabesh Gyawali, Jagat Budhathoki, Yue Ma, Kazuo Nagasawa, Hamza Balci
Nucl. Acids Res. 2019, accepted. DOI:10.1093/nar/gkz803


 [177] Synthesis of Isoxazolidines by Intramolecular Hydroamination of N-Alkoxyamides in the Presence of a Visible-Light Photoredox Catalyst


 


Hayate Ishizuka, Kanna Adachi, Minami Odagi, Kazuo Nagasawa
Bull. Chem. Soc. Jpn. 2019, 92, 1447-1449.  DOI:10.1246/bcsj.20190127


 [176] Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities


 


Hisao Masai, Rino Fukatsu, Naoko Kakusho, Yutaka Kanoh, Kenji Moriyama, Yue Ma, Keisuke Iida, Kazuo Nagasawa
Sci. Rep. 2019, 9, Article number: 8618. DOI: 10.1038/s41598-019-44736-9 


 [175] Impact of Small Molecules on Intermolecular G-quadruplex Formation


 


Prabesh Gyawali, Keshav GC, Yue Ma, Sanjaya Abeysirigunawardene, Kazuo Nagasawa, Hamza Balci
Molecules  2019, 24, Article number:1570. DOI:10.3390/molecules24081570  


[174] Stereoselective Synthesis of Four Calcitriol Lactone Diastereomers at C23 and C25


 

   

Akiko Nagata, Yusuke Akagi, Shadi Sedghi Masoud, Masahiro Yamanaka, Atsushi Kittaka, Motonari Uesugi, Minami Odagi, Kazuo Nagasawa
J. Org. Chem. 2019, 84, 7630-7641. DOI:10.1021/acs.joc.9b00403


[173] Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole


 


Keisuke Iida, Yamato Tsushima, Yue Ma, Shadi Sedghi Masoud, Mai Sakuma, Tomomi Yokokawa, Wataru Yoshida, Kazunari Ikebukuro, Kazuo Nagasawa
Bioorg. Med. Chem. 2019, 27, 1742-1746. DOI:10.1016/j.bmc.2019.02.056


[172] Synthesis and Telomeric G-quadruplex-stabilizing Ability of Macrocyclic Hexaoxazoles bearing Three Side Chains


 


Yue Ma, Keisuke Iida, Shogo Sasaki, Takatsugu Hirokawa, Heddi Brahim, Anh Tuân Phan, Kazuo Nagasawa
Molecules 2019, 24, Article number:263. DOI:10.3390/molecules24020263


[171] Synthesis of All Stereoisomers of RK460 and Evaluation of Activity and Selectivity as Abscisic Acid Receptor Antagonists


 


Yu Mikame, Kazuko Yoshida, Daisuke Hashizume, Go Hirai, Kazuo Nagasawa, Hiroyuki Osada, Mikiko Sodeoka
Chem. Eur. J. 2019, 25, 3496-3500. DOI:10.1002/chem.201806056


[170] Binding of a Telomestatin Derivative Changes Mechanical Anisotropy of Human Telomeric G-quadruplex


 


Sagun Jonchhe, Chiran Ghimire, Yunxi Cui, Shogo Sasaki, Soyoung Park, Keisuke Iida, Kazuo Nagasawa, Hiroshi Sugiyama, Hambin Mao
Angew. Chem., Int. Ed. 201958, 877-881. DOI:10.1002/anie.201811046


[169] IDENTIFICATION OF TARGET PROTEIN FOR BATZELLADINES AS CD4


 


Jun Shimokawa, Kazuo Nagasawa
Heterocycles 201999, 521-533 DOI:10.3987/COM-18-S(F)49



[168] Random formation of G-quadruplexes in human telomere overhangs leads to a kinetic folding pattern with targetable vacant G-tracts


 


Jibin Abraham Punnoose, Yue Ma, Mohammed Enamul Hoque, Yunxi Cui, Shogo Sasaki, Athene Huixin Guo, Kazuo Nagasawa, Hambin Mao
Biochemistry 201857, 6946-6955 DOI:10.1021/acs.biochem.8b00957


[167] Molecular architecture of G-quadruplex structures generated on duplex Rif1 binding sequences


 


Hisao Masai, Naoko Kakusho, Rino Fukatsu, Yue Ma, Keisuke Iida, Yutaka Kanoh, Kazuo Nagasawa
J. Biol. Chem. 2018, 293, 17033-17049. DOI:10.1074/jbc.RA118.005240


[166] A Force Sensor that Converts Fluorescence Signal into Force Measurement Utilizing Short Looped DNA


 


Golam Mustafa, Cho-Ying Chuang, William A. Roy, Mohamed M. Farhath, Nilisha Pokhrel, Yue Ma, Kazuo Nagasawa, Edwin Antony, Matthew J. Comstock, Soumitra Basu, Hamza Balci
Biosens. Bioelectron. 2018121, 34-40. DOI:10.1016/j.bios.2018.08.073


[165] Analysis of interaction between telomeric i‐motif DNA and a cyclic tetraoxazole compound


 


Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Asrien Marchand, Fernaldo Richtia Winnerdy, Valérie Gabelica, Anh Tuan Phan, Masato Katahira, Kazuo Nagasawa
ChemBioChem 201819, 2268-2272. DOI:10.1002/cbic.201800425


[164] Development of G-quadruplex ligand for selective induction of parallel-type topology


 

   

Yue Ma, Yamato Tsushima, Mai Sakuma, Shogo Sasaki, Keisuke Iida, Sachiko Okabe, Hiroyuki Seimiya, Takatsugu Hirokawa, Kazuo Nagasawa
Org. Biomol. Chem. 201816, 7375-7382. DOI:10.1039/C8OB01702F


[163] Esterification of PQQ enhances blood-brain barrier permeability and inhibitory activity against amyloidogenic protein fibril formation


 


Kaori Tsukakoshi, Wataru Yoshida, Masaki Kobayashi, Natsuki Kobayashi, Jihoon Kim, Toshisuke Kaku, Toshitsugu Iguchi, Kazuo Nagasawa, Ryutaro Asano, Kazunori Ikebukuro, Koji Sode
ACS Chem. Neursci. 20189, 2898-2903. DOI:10.1021/acschemneuro.8b00355


[162] Asymmetric Epoxidation of 1,4-Naphthoquinones Catalyzed by Guanidine–Urea Bifunctional Organocatalyst


 


Masaki Kawaguchi, Katsuhiro Nakano, Keisuke Hosoya, Tatsuya Orihara, Masahiro Yamanaka , Minami Odagi, Kazuo Nagasawa
Org. Lett. 2018, 20, 2811-2815. DOI:10.1021/acs.orglett.8b00641


[161] Synthesis of a Quaternary N,N'-Aminal-Containing A-E Ring System of Palau'amine via Enamide-type Overman Rearrangement Reaction


 


Takuya Imaoka, Makoto Iwata and Kazuo Nagasawa
Eur. J. Org. Chem. 2018, 2018, 2572-2578. DOI:10.1002/ejoc.201800086


[160] A synthesis of 2,6,7-trisubstituted prenylated indole


 


Motoki Shiozawa, Keisuke Iida, Minami Odagi, Masahiro Yamanaka, Kazuo Nagasawa
J. Org. Chem. 2018, 83, 7276-7280. DOI:10.1021/acs.joc.7b03273


[159] Identification of G-quadruplex clusters by high-throughput sequencing of whole-genome amplified products with a G-quadruplex ligand


 


Wataru Yoshida, Hiroki Saikyo, Kazuhiko Nakabayashi, Hitomi Yoshioka, Daniyah Habiballah Bay, Keisuke Iida, Tomoko Kawai, Kenichiro Hata, Kazunori Ikebukuro, Kazuo Nagasawa, Isao Karube
Sci. Rep. 2018, 8, Article number:3116. DOI:10.1038/s41598-018-21514-7


[158] Total Synthesis of (+)-Gracilamine Based on Oxidative Phenolic Coupling Reaction and Determination of its Absolute Configuration


 


Minami Odagi, Yoshiharu Yamamoto, Kazuo Nagasawa
Angew. Chem., Int. Ed. 201857, 2229-2232. DOI:10.1002/anie.201708575



[157] Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk


 


Moshe Shashar, Mostafa E. Belghasem, Shinobu Matsuura. Faisal Alousi, Keshab Rijal, Vijaya B. Kolachalama, Mercedes Balcells, Minami Odagi, Kazuo Nagasawa, Joel M. Henderson, Amitabh Gautam, Jean Francis, Kumaran Kolandaivelu, David H. Sherr, Katya Ravid, Vipul C. Chitalia
Sci. Transl. Med. 2017, 9, eaam8475. DOI:10.1126/scitranslmed.aam8475


[156] FAN1 acts in concert with ubiquitylated PCNA to alleviate replication stress and preserve genome integrity


 


Antonio Porro, Matteo Berti, Julia Pizzolato, Anja Saxer, Yue Ma, Kazuo Nagasawa, Alessandro A. Sartori, Josef Jiricny
Nat. Commun. 2017, 8, Article number:1073. DOI:10.1038/s41467-017-01074-6


[155] Identification of G-quadruplex structures that possess transcriptional regulating functions in the Dele and Cdc6 CpG islands


 


Daniyah H. Bay, Annika Busch, Fred Lisdat, Keisuke Iida, Kazunori Ikebukuro, Kazuo Nagasawa, Isao Karube, Wataru Yoshida
BMC Mol. Biol. 2017, 18, 17. DOI:10.1186/s12867-017-0094-z


[154] Guanidinium Hydroiodide/Cumene Hydroperoxide-Mediated Intermolecular Oxidative Coupling Reaction of β-Ketoamides with Oxindoles


 


Takanari Kato, Koji Yasui, Minami Odagi, Kazuo Nagasawa
Adv. Synth. Catal. 2017, 359, 2881-2889. DOI:10.1002/adsc.201700266


[153] Structure-dependent binding of hnRNP A1 to telomere RNA


 


Xiao Liu, Takumi Ishizuka, Hong-Liang Bao, Kei Wada, Yuuma Takada, Keisuke Iida, Kazuo Nagasawa, Danzhou Yang, and Yan Xu
J. Am. Chem. Soc. 2017, 139, 7533-7539. DOI:10.1021/jacs.7b01599


[152] Adaptive and Specific Recognition of Telomeric G-quadruplexes via Polyvalency Induced Unstacking of Binding Units


 


Jibin Abraham Punnoose, Yue Ma, Yuanyuan Li, Mai Sakuma, Shankar Mandal, Kazuo Nagasawa, Hanbin Mao
J. Am. Chem. Soc. 2017, 139, 7476-7484. DOI:10.1021/jacs.7b00607


[151] Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole


 


Takahiro Nakamura, Sachiko Okabe, Haruka Yoshida, Keisuke Iida, Yue Ma, Shogo Sasaki, Takao Yamori, Kazuo Shin-ya, Ichiro Nakano, Kazuo Nagasawa and Hiroyuki Seimiya
Sci. Rep. 2017, 7, Article number:3605. DOI:10.1038/s41598-017-03785-8


[150] Total Synthesis of Rishirilide B Based on Organocatalytic Oxidative Kinetic Resolution: Revision of Absolute Configuration of (+)-Rishirilide B


 


Minami Odagi, Kota Furukori, Kan Takayama, Keiichi Noguchi, Kazuo Nagasawa
Angew. Chem., Int. Ed. 2017, 56, 6609-6612. DOI:10.1002/anie.201701431
Highlighted by Synfacts


[149] Synthesis and identification of key biosynthetic intermediates for formation of the tricyclic skeleton of saxitoxin


 


Shigeki Tsuchiya, Yuko Cho, Renpei Yoshioka, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, and Mari Yotsu-Yamashita

Angew. Chem., Int. Ed. 2017, 56 , 5327-5331. DOI:10.1002/anie.201612461


[148] A G-quadruplex structure at the 5′ end of the H19 coding region regulates H19 transcription


 


Mitsuko Fukuhara, Yue Ma, Kazuo Nagasawa, Fumiko Toyoshima
Sci. Rep. 2017, 7, Article number: 45815. DOI:10.1038/srep45815


[147] Oxidative kinetic resolution of cis-fused tricyclic 1-tetralone derivatives by guanidine-bisurea bifunctional organocatalyst


 


Minami Odagi, Keisuke Hosoya, Yoshiharu Yamamoto, Kazuo Nagasawa
Synlett 2017, 28, 1305-1309. DOI:10.1055/s-0036-1588151


[146] Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP


 


Lisa Asano, Mizuki Watanabe, Yuta Ryoden, Kousuke Usuda, Takuya Yamaguchi, Bilon Khambu, Megumi Takashima, Shin-ichi Sato, Juro Sakai, Kazuo Nagasawa, Motonari Uesugi
Cell Chem. Biol. 2017, 24, 207-217. DOI:10.1016/j.chembiol.2016.12.017
Highlighted by 朝日新聞DIGITAL, WORLD PHARMAN NEWSKyoto Univ., iCeWS, EurekAlert! and ASIA RESEARCH NEWS


[145] Total Synthesis of Pyrrole-Imidazole Alkaloid (+)-Cylindradine B


 


Makoto Iwata, Yuko Kamijoh, Eri Yamamoto, Masahiro Yamanaka, and Kazuo Nagasawa
Org. Lett. 2017, 19, 420-423. DOI:10.1021/acs.orglett.6b03722



[144] A Single Molecule Study of a Fluorescently Labeled Telomestatin Derivative and G-Quadruplex Interactions


 


Parastoo Maleki, Yue Ma, Keisuke Iida, Kazuo Nagasawa, Hamza Balci
Nucl. Acids Res. 2016, 45, 288-295. DOI:10.1093/nar/gkw1090


[143] Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers


 


Kaori Tsukakoshi, Yuri Ikuta, Koichi Abe, Wataru Yoshida, Keisuke Iida, Yue Ma, Kazuo Nagasawa, Koji Sode and Kazunori Ikebukuro
Chem. Commun. 2016, 52, 12646-12649. DOI:10.1039/c6cc07552e


[142] Regulation mechanism of the vitamin D receptor by vitamin D lactam derivatives


 


Lisa Asano, Tsuyoshi Waku, Rumi Abe, Naoyuki Kuwabara, Ichiaki Ito, Junn Yanagisawa, Kazuo Nagasawa, Toshiyuki Shimizu
FEBS Lett. 2016, 590, 3270-3279. DOI:10.1002/1873-3468.12348


[141] Total Synthesis of 11-Saxitoxinethanoic Acid and Evaluation of its Inhibitory Activity on Voltage-gated Sodium Channels


 


Chao Wang, Mana Oki, Toru Nishikawa, Daisuke Harada, Mari Yotsu-Yamashita and Kazuo Nagasawa
Angew. Chem., Int. Ed. 2016, 55, 11600-11603. DOI:10.1002/anie.201604155


[140] Synthesis of 1α- and 1β-amino-25-hydroxyvitamin D3


 


Yusuke Akagi, Kosuke Usuda, Tomoe Tanami, Koji Yasui, Lisa Asano, Motonari Uesugi, Kazuo Nagasawa
Asian. J. Org. Chem. 2016, 10, 1247-1252. DOI:10.1002/ajoc.201600300


[139] Guanidinium Iodide/Urea Hydrogen Peroxide-Catalyzed Azidation of β-Dicarbonyl Compounds with Trimethylsilyl Azide


 


Koji Yasui, Kohei Kojima, Takanari Kato, Minami Odagi, Masaru Kato, and Kazuo Nagasawa
Tetrahedron 2016, 72, 5350-5354. DOI:10.1016/j.tet.2016.07.015


[138] Detection of DNA methylation of G-quadruplex and i-motif-forming sequences by measuring the initial elongation efficiency of PCR


 


Wataru Yoshida, Hitomi Yoshioka, Daniyah Habiballah Bay, Keisuke Iida, Kazunori Ikebukuro, Kazuo Nagasawa, Isao Karube
Anal. Chem. 2016, 88, 7101-7107. DOI:10.1021/acs.analchem.6b00982


[137] Synthesis of 24,24-difluoro-1,3-cis-25-dihydroxy-19-norvitamin D3 derivatives and evaluation of their vitamin D receptor-binding affinity


 


Tanima Biswas, Yusuke Akagi, Kosuke Usuda, Koji Yasui, Isao Shimizu, Mayumi Okamoto, Motonari Uesugi, Seijiro Hosokawa, Kazuo Nagasawa
Biol. Pharm. bull. 2016, 39, 1387-1391. DOI:10.1248/bpb.b16-00316


[136] Synthesis of diasteromers of 1,3-cis-25-dihydroxy-19-norvitamin D3


 


Kosuke Usuda, Tanima Biswas, Takuya Yamaguchi, Yusuke Akagi, Koji Yasui, Motonari Uesugi, Isao Shimizu, Seijiro Hosokawa, Kazuo Nagasawa
Chem. Pharm. bull. 2016, 64, 1190-1195. DOI:10.1248/cpb.c16-00311


[135] Design and synthesis of unsymmetric macrocyclic hexaoxazole compounds with ability to induce distinct G-quadruplex topologies in telomeric DNA


 


Mai Sakuma, Yue Ma, Yamato Tsushima, Keisuke Iida, Takatsugu Hirokawa, Kazuo Nagasawa
Org. Biomol. Chem. 2016, 14, 5109-5116. DOI:10.1039/C6OB00437G


[134] Asymmetric α-amination of β-keto esters using guanidine-bisurea bifunctional organocatalyst


 


Minami Odagi, Yoshiharu Yamamoto, Kazuo Nagasawa
Beilstein J. Org. Chem. 2016, 12, 198-203. DOI:10.3762/bjoc.12.22


[133] Biosynthetic route towards saxitoxin and shunt pathway


 


Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, Mari Yotsu-Yamashita
Sci. Rep. 2016, 6, Article number: 20340. DOI:10.1038/srep20340


[132] Synthesis of (+)-trans-dihydrolycoridine using orgacocatalytic enantioselective Friedel-Crafts reaction


 


Masaru Kato, Koji Yasui, Masahiro Yamanaka, Kazuo Nagasawa
Asian J. Org. Chem. 2016, 5, 380-388. DOI:10.1002/ajoc.201500469


[131] Design, Synthesis and Evaluation of an L-Dopa-Derived Macrocyclic Hexaoxazole (6OTD) as a G-Quadruplex-Selective Ligand


 


Takahiro Nakamura, Yue Ma, Keisuke Iida, Terumi Ohtake, Hiroyuki Seimiya, Kazuo Nagasawa
Heterocycles, 2016, 92, 305-315. DOI:10.3987/COM-15-13383



[130] Entropy-driven 1,2-Type Friedel-Crafts Reaction of Phenols with N-Boc Aldimines


 

   

Masaru Kato, Shogo Hirao, Katsuhiro Nakano, Makoto Sato, Masahiro Yamanaka, Yoshihiro Sohtome, Kazuo Nagasawa
Chem. Eur. J. 2015, 21, 18606-18612. DOI:10.1002/chem.201503280


[129] Rif1 binds to G-quadruplex and suppresses replication over a long distance


 


Yutaka Kanoh, Seiji Matsumoto, Rino Fukatsu, Naoko Kakusho, Nobuaki Kono, Claire Renard-Guilet, Koji Masuda, Keisuke Iida, Kazuo Nagasawa, Katsuhiko Shirahige, Hisao Masai
Nat. Struct. Mol. Biol. 2015, 22, 889-897. DOI:10.1038/nsmb.3102


[128] Development of Guanidine-Bisurea Bifunctional Organocatalyst with a Chiral Pyrrolidine Moiety and Application to α-Hydroxylation of Tetralone-Derived β-Keto Esters


 


Minami Odagi, Kan Takayama, Makoto Sato, Masahiro Yamanaka, Kazuo Nagasawa
Molecules 2015, 20, 12590-12598. DOI:10.3390/molecules200712590


[127] Time-resolved crystal structures of the reaction intyermediate of nitrile hydrase reveal a role for the cystein-sulfenic acid ligand as a catalyst nucleophile


 


Yasuaki Yamanaka, Yuki Kato, Koichi Hashimoto, Keisuke Iida, Kazuo Nagasawa, Hiroshi Nakayama, Naoshi Dohmae, Keiichi Noguchi, Takumi Noguchi, Masafumi Yohda, Masafumi Odaka
Angew. Chem., Int. Ed. 2015, 54, 10763-10767. DOI:10.1002/anie.201502731


[126] Synthesis of a tricyclic bisguanidine compound structurally related to saxitoxin and its identification in paralytic shellfish toxins-producing microorganisms


 


Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, Mari Yotsu-Yamashita
Chem. Eur. J. 2015, 21, 7835-7840. DOI:10.1002/chem.201500064


[125] Development of Guanidine-Bisurea Bifunctinaol Organocatalyst Bearing Chirality at the Inner and Outer Sides of Urea Groups, and Application to Enantioselective α-Hydroxylation of Pyranoindolizine Intermediate for Camptothecin Synthesis


 


Minami Odagi, Tatsuya Watanabe, Kazuo Nagasawa
Symmetry 2015, 7, 43-52. DOI:10.3390/sym7010043


[124] Origin of stereocontorol in guanidine-bisurea bifunctional organocatalyst that promotes α-hydroxylation of tetralone-derived β-ketoesters: Asymmetric synthesis of β- or γ-substituted tetralone derivatives via organocatalytic oxidative kinetic resolution


 


Minami Odagi, Kota Furukori, Yoshiharu Yamamoto, Makoto Sato, Keisuke Iida, Masahiro Yamanaka, Kazuo Nagasawa
J. Am. Chem. Soc. 2015, 137, 1909-1915. DOI:10.1021/ja511149y
Highlighted by ACS Select Virtual Issue "Organocatalyst"


[123] Guanidium Iodine-Catalyzed Oxidative α-Nitroalkylation of β-Ketoamides


 


Koji Yasui, Takanari Kato, Kohei Kojima, Kazuo Nagasawa
Chem. Commun. 2015, 51, 2290-2293. DOI:10.1039/C4CC08581G


[122] Conformational changes and cation ejection upon ligand binding to human telomeric DNA G-quadruplexes


 


Adrien Marchand, Anton Granzhan, Keisuke Iida, Yamato Tsushima, Yue Ma, Kazuo Nagasawa, Marie-Paule Teulade-Fichou, Vale'rie Gabelica
J. Am. Chem. Soc. 2015, 137, 750-756. DOI:10.1021/ja5099403



[121] 2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP



Hiromi Hiyoshi, Natsuka Goto, Mai Tsuchiya, Keisuke Iida, Yuka Nakajima, Naoya Hirata, Yasunari Kanda, Kazuo Nagasawa, Junn Yanagisawa
Sci. Rep. 2014, 4, Article number:7095. DOI:10.1038/srep07095


[120] Direct Quantification of Loop Interaction and π-π Stacking for G-quadruplex Stability at the Sub-molecular Level


 


Chiran Ghimire, Soyoung Park, Keisuke Iida, Philip Yangyuoru, Haruka Otomo, Zhongbo Yu, Kazuo Nagasawa, Hiroshi Sugiyama, and Hanbin Mao
J. Am. Chem. Soc. 2014, 136, 15537-15544. DOI:10.1002/ja503585h


[119] Synthesis of an advance model of zetekitoxin AB focusing on N-acylisoxazolidine amide structure corresponding to C13~C17


 


Toru Nishikawa, Chao Wang, Takafumi Akimoto, Hiroyuki Koshino, Kazuo Nagasawa
Asian j. Org. Chem. 2014, 3, 1308-1311. DOI:10.1002/ajoc.201402206


[118] Synthesis of Macrocyclic Penta- and Tetraoxazoles as G-Quadruplex Ligands


 


Shadi Sedghi Masoud, Tsushima Yamato, Keisuke Iida, Kazuo Nagasawa
Heterocycles 2014, 90, 866-873. DOI:10.3987/COM-14-S(K)90


[117] Synthesis of 19-nor-vitamin D A-ring synthons via ring-closing olefin metathesis (RCM) reaction


 


Yu Nagai, Tomoe Tanami, Junko Abe, Hazuki Nagai, Toru Hamamizu, Kaichiro Kominato, Keisuke Iida, Kazuo Nagasawa
Asian J. Org. Chem. 2014, 3, 994-999. DOI:10.1002/ajoc.201402109
Selected as a Very Important Paper (VIP)


[116] Total synthesis of (+)-Cylindradine A


 


Makoto Iwata, Kyohei Kanoh, Takuya Imaoka, Kazuo Nagasawa
Chem. Commun. 2014, 50, 6991-6994. DOI:10.1039/C4CC00137K


[115] Development of Novel Guanidine-Bisurea Bifunctional Organocatalysts and Their Application to Asynnetric α-Hydroxylation of Tetralone-Derived β-Keto Esters


 


Minami Odagi, Kan Takayama, Kota Furukori, Tatsuya Watanabe, Kazuo Nagasawa
Aust. J. Chem. 2014, 67, 1017-1020. DOI:10.1071/CH14144


[114] Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the binoflagellate Alexandrium tamarense (Axat-2)


 


Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, Mari Yotsu-Yamashita
Org. Biomol. Chem. 2014, 12, 3016-3020. DOI:10.1039/C4OB00071D


[113] Asymmetric Michael Reaction of Nitroolefins with beta-Dicarbonyl Compounds Catalysed by 1,3-Diamine-Tethered Guanidine-Thiourea Bifunctional Organocatalysts


 


Natsuko Horitsugi, Kohei Kojima, Koji Yasui, Yoshihiro Sohtome, Kazuo Nagasawa
Asian J. Org. Chem. 2014, 3, 445-448. DOI:10.1002/ajoc.2011402002R1


[112] Identification of a Novel Compound That Suppresses Breast Cancer Invasiveness by Inhibiting Transfoming Growth Factor-beta Signaling via Estrogen Receptor α


 


Natsuka Goto, Hiromi Hiyoshi, Ichiaki Ito, Keisuke Iida, Yuka Nakajima, Kazuo Nagasawa, Junn Yanagisawa
J. Cancer 2014, 5, 336-343. DOI:10.7150/jca.7202


[111] Asymmetric α-Hydroxylation of Lactone with Vinylogous Pyridone using Guanidine-Urea Bifunctional Organocatalyst: Catalystic Enantioselective Synthesis of a Key Intermediate for (20S)-Camptothecin Analogues


 


Tatusya Watanabe, Minami Odagi, Kota Furukori, Kazuo Nagasawa
Chem. Eur. J. 2014, 20, 591-597. DOI:10.1002/chem.201303663



[110] A nonclassical vitamin D receptor pathway suppresses renal fibrosis


 


Ichiaki Ito, Tsuyoshi Waku, Masato Aoki, Rumi Abe, Yu Nagai, Tatsuya Watanabe, Yuka Nakajima, Ichiro Ohkido, Keitaro Yokoyama, Hiroyuki Miyachi, Toshiyuki Shimizu, Akiko Murayama, Hiroyuki Kishimoto, Kazuo Nagasawa, Junn Yanagisawa
J. Clin. Invest. 2013, 123, 4579-4594. DOI:10.1172/JCI67804


[109] Fluorescent ligand-mediated screening of G-quadruplex structure using a DNA microarray


 

   

Kesuke Iida, Takahiro Nakamura, Wataru Yoshida, Masayuki Tera, Kazuhiko Nakabayashi, Kenichiro Hata, Kazunori Ikebukuro, Kazuo Nagasawa
Angew. Chem., Int. Ed. 2013, 52, 12052-12055. DOI:10.1002/anie.201305366
Highlighted by Nikkan BizLine and TUAT press release


[108] Asymmetric α-hydroxylation of Tetralone Derived β-Ketoesters using Guanidine-Urea Bifunctional Organocatalyst in the Presence of Cumene Hydroperoxide


 


Minami Odagi, Kota Furugori, Tatsuya Watanabe, Kazuo Nagasawa
Chem. Eur. J. 2013, 19, 16740-16745. DOI:10.1002/chem.201303006


[107] Synthesis of Macrocyclic Dimer of Cyclic Hexaoxazole and Examination of Its Interaction with Telomeric Oligonucleotide


 


Keisuke Iida, Gen Tsubouchi, Takahiro Nakamura, Kazuo Nagasawa
Heterocycles 2014, 88, 1287-1298. DOI:10.3987/COM-13-S(S)97


[106] Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative


 


Wan Jun Chung, Brahim Heddi, Masayuki Tera, Keisuke Iida, Kazuo Nagasawa, Anh Tuân Phan
J. Am. Chem. Soc. 2013, 135, 13495-13501. DOI:10.1021/ja405843r
Highlighted by Faculty of 1000


[105] Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channel


 


Takafumi Akimoto, Asako Masuda, Mari Yotsu-Yamashita, Takatsugu Hirokawa, Kazuo Nagasawa
Org. Biomol. Chem. 2013, 11, 6642-6649. DOI:10.1039/C3OB41398
Highlighted by Pubadvanced


[104] A tandem Friedel-Crafts based method for the construction of tricyclic pyrroquinoline skeleton and its application to the synthesis of ammosamide B


 


Yohei Takayama, Tatsuya Yamada, Shinya Tatekabe, Kazuo Nagasawa
Chem. Commun. 2013, 49, 6519-6521. DOI:10.1039/C3CC42463D


[103] Evaluation of the Interaction between Long Telomeric DNA and Macrocyclic Hexaoxazole (6OTD) Dimer of a G-quadruplex Ligand


 


Keisuke Iida, Satoki Majima, Takahiro Nakamura, Hiroyuki Seimiya, Kazuo Nagasawa
Molecules 2013, 18, 4328-4341. DOI:10.3390/molecules18044328


[102] Sequential Enantiodivergent Organocatalysis: Reversibility in Enantioswitching Controlled by a Conformationally Flexible Guanidine/Bisthiourea Organocatalyst


 


Yoshihiro Sohtome, Takahisa Yamaguchi, Shinji Tanaka, Kazuo Nagasawa
Org. Biomol. Chem. 2013, 11, 2780-2786. DOI:10.1039/C3OB27479A


[101] Interaction of long telomeric DNAs with macrocyclic hexaoxazole as a G-quadruplex ligands


 


Keisuke Iida, Gen Tsubouchi, Takahiro Nakamura, Satoki Majima, Hiroyuki Seimiya, Kazuo Nagasawa
Med. Chem. Commun. 2013, 4, 260-264. DOI:10.1039/C2MD20234D


[100] Intramolecular 1,3-Dipolar Cycloaddition-Mediated Stereoselective Synthesis of Disubstituted Cyclopentane, a Simple Model for Cyclopentane Ring System of Polycyclic Oroidine Alkaloids


 


Yusuke Fukahori, Yohei Takayama, Takuya Imaoka, Osamu Iwamoto, Kazuo Nagasawa
Chem. Asian J. 2013, 8, 244-250. DOI:10.1002/asia.201200820



[99] Synthesis of vitamin D3 derivatives with nitrogen-linked substituents at A-ring C-2 and evaluation of their vitamin D receptor-mediated transcriptional activity


 


Junko Abe, Yu Nagai, Rui Higashikuni, Keisuke Iida, Takatsugu Hirokawa, Hazuki Nagai, Kaichiro Kominato, Toshio Tsuchida, Michiko Hirata, Masaki Inada, Chisato Miyaura, Kazuo Nagasawa
Org. Biomol. Chem. 2012, 10, 7826-7836. DOI:10.1039/C2OB26017D


[98] A Caged Ligand for a Telomeric G-Quadruplex


 


Takahiro Nakamura, Keisuke Iida, Masayuki Tera, Kazuo Shin-ya, Hiroyuki Seimiya, Kazuo Nagasawa
ChemBioChem 2012, 13, 774-777. DOI:10.1002/cbic.201200013

 


[97] Agrocybynes A-E from the culture broth of Agrocybe praecox


 


Keiji Fushimi, Kota Anzai, Shinji Tokuyama, Yoshikazu Kiriiwa, Noriyuki Matsumoto, Atsushi Sekiya, Daisuke Hashizume, Kazuo Nagasawa, Hirofumi Hirai, Hirokazu Kawagishi
Tetrahedron 2012, 68, 1262-1265. DOI:10.1016/j.tet.2011.11.049


[96] Design and Synthesis of G-Quadruplex Ligands Bearing Macrocyclic Hexaoxazoles with Four-Way Side Chains


 


Keisuke Iida, Satoki Majima, Terumi Ootake, Masayuki Tera, Kazuo Shin-ya, Kazuo Nagasawa
Heterocycles 2012, 84, 401-404. DOI:10.3987/COM-11-S(P)88



[95] Enantioselective epoxidation of α,β-unsaturated ketones catalyzed by stapled helical l-Leu-based peptides


 


Yosuke Demizu, Nanako Yamagata, Saori Nagoya, Yukiko Sato, Mitsunobu Doi, Masakazu Tanaka, Kazuo Nagasawa, Haruhiro Okuda, Masaaki Kurihara
Tetrahedron 2011, 67, 6155-6165. DOI:10.1016/j.tet.2011.06.075


[94] Synthesis of Skeletal Analogues of Saxitoxin Derivatives and Evaluation of Their Inhibitory Activity on Sodium Ion Channels NaV1.4 and NaV1.5


 


Ryoko Shinohara, Takafumi Akimoto, Osamu Iwamoto, Takatsugu Hirokawa, Mari Yotsu-Yamashita, Kaoru Yamaoka, Kazuo Nagasawa
Chem. Eur. J. 2011, 17, 12144-12151. DOI:10.1002/chem.201101058
 


[93] Development of a novel biosensing system based on the structural change of a polymerized guanine-quadruplex DNA nanostructure


 


Yo Morita, Wataru Yoshida, Nasa Savory, Sung Woong Han, Masayuki Tera, Kazuo Nagasawa, Chikashi Nakamura, Koji Sode, Kazunori Ikebukuro
Biosens. Bioelectron. 2011, 26, 4837-4841. DOI:10.1016/j.bios.2011.05.050


[92] Organocatalytic Asymmetric Synthesis of N,N-Bis(dihydrofuranyl)hydroxyamines: A Cascade Reaction Involving Friedel-Crafts Alkylation, Internal Redox Reaction, and Umpolung


 


Yoshihiro Sohtome, Yoshihiro Yamaguchi, Bongki Shin, Kazuo Nagasawa
Chem. Lett. 2011, 40, 843-845. DOI:10.1246/cl.2011.843


[91] Enantioselective Phospha-Michael Reaction of Diphenyl Phosphonate with Nitroolefins Utilizing Conformationally Flexible Guanidinium/Bisthiourea Organocatalyst: Assembly-State Tunability in Asymmetric Organocatalysis


 


Yoshihiro Sohtome, Natsuko Horitsugi, Rika Takagi, Kazuo Nagasawa
Adv. Synth. Cat. 2011, 353, 2631-2636. DOI:10.1002/adsc.201100219


[90] Osteoclast-forming suppressing compounds, gargalols A, B and C, from the edible mushroom Grifola gargal


 


Jing Wua, Jae-Hoon Choi, Miyuki Yoshida, Hirofumi Hirai, Etsuko Harada, Kikuko Masuda, Tomoyuki Koyama, Kazunaga Yazawa, Keiichi Noguchi, Kazuo Nagasawa, Hirokazu Kawagishi
Tetrahedron 2011, 67, 6576-6581. DOI:10.1016/j.tet.2011.05.091


[89] Analysis of unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy


 


Yosuke Amemiya, Yui Furunaga, Keisuke Iida, Masayuki Tera, Kazuo Nagasawa, Kazunori Ikebukuro, Chikashi Nakamura
Chem. Commun. 2011, 47, 7485-7487. DOI:10.1039/C0CC05781A


[88] Linking Conformational Flexibility and Kinetics: Catalytic 1,4-Type Friedel–Crafts Reactions of Phenols Utilizing 1,3-Diamine-Tethered Guanidine/Bisthiourea Organocatalysts


 


Yoshihiro Sohtome, Bongki Shin, Natsuko Horitsugi, Keiichi Noguchi, Kazuo Nagasawa
Chem. Asian. J. 2011, 6, 2463-2470. DOI:10.1002/asia.201100363


[87] Design of a stabilized short helical peptide and its application to catalytic enantioselective epoxidation of (E)-chalcone


 


Nanako Yamagata, Yosuke Demizua, Yukiko Sato, Mitsunobu Doi, Masakazu Tanakad, Kazuo Nagasawa, Haruhiro Okuda, Masaaki Kurihara
Tetrahedron Lett. 2011, 52, 798-801. DOI:10.1016/j.tetlet.2010.12.030


[86] (S)-Stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor


 


Takayuki Doi, Kazuaki Shibata, Masahito Yoshida, Motoki Takagi, Masayuki Tera, Kazuo Nagasawa, Kazuo Shin-ya, Takashi Takahashi
Org. Biomol. Chem. 2011, 9, 387-393. DOI:10.1039/C0OB00513D


[85] Design and Synthesis of Telomestatin Derivatives Containing Methyl Oxazole and Their G-Quadruplex Stabilizing Activities


 


Satoki Majima, Masayuki Tera, Keisuke Iida, Kazuo Shin-ya, Kazuo Nagasawa
Heterocycles 2011, 82, 1345-1357. DOI:10.3987/COM-10-S(E)85



[84] A Novel Glucosylation Reaction on Anthocyanins Catalyzed by Acyl-Glucose–Dependent Glucosyltransferase in the Petals of Carnation and Delphinium


 


Yuki Matsuba, Nobuyuki Sasaki, Masayuki Tera, Masachika Okamura, Yutaka Abe, Emi Okamoto, Haruka Nakamura, Hisakage Funabashi, Makoto Takatsu, Mikako Saito, Hideaki Matsuoka Kazuo Nagasawa, Yoshihiro Ozeki
Plant Cell 2010, 22, 3374-3389. DOI:10.​1105/​tpc.​110.​077487


[83] Solvent-Dependent Enantiodivergent Mannich-Type Reaction: Utilizing a Conformationally Flexible Guanidine/Bisthiourea Organocatalyst


 


Yoshihiro Sohtome,. Shinji Tanaka, Keisuke Takada, Takahisa Yamaguchi, Kazuo Nagasawa
Angew. Chem., Int. Ed. 2010, 49, 9254-9257. DOI:10.1002/anie.201005109


[82] Entropy-Controlled Catalytic Asymmetric 1,4-Type Friedel–Crafts Reaction of Phenols Using Conformationally Flexible Guanidine/Bisthiourea Organocatalyst


 


Yoshihiro Sohtome, Bongki Shin, Natsuko Horitsugi, Rika Takagi, Keiichi Noguchi, Kazuo Nagasawa
Angew. Chem., Int. Ed. 2010, 49, 7299-7303. DOI:10.1002/anie.201003172


[81] Total Synthesis of (+)-Dibromophakellin and (+)-Dibromophakellstatin


 


Takuya Imaoka, Takafumi Akimoto, Osamu Iwamoto, Kazuo Nagasawa
Chem. Asian. J. 2010, 5, 1810-1816. DOI:10.1002/asia.201000213


[80] Visualization of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole.


 


Masayuki Tera, Keisuke Iida, Kazunori Ikebukuro, Hiroyuki Seimiya, Kazuo Shin-ya, Kazuo Nagasawa
Org. Biomol. Chem. 2010, 8, 2749-2755. DOI:10.1039/C002117B


[79] Total Synthesis of (+)-Decarbamoylsaxitoxin and (+)-Gonyautoxin 3


 


Osamu Iwamoto, Kazuo Nagaswa
Org. Lett. 2010, 12, 2150-2153. DOI:10.1021/ol1006696


[78] Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties


 


Keisuke Iida, Masayuki Tera, Takatsugu Hirokawa, Kazuo Shin-ya, Kazuo Nagasawa
J. Nucleic Acids 2010, Article number:217627. DOI:10.4061/2010/217627


[77] Disabling c-Myc in Childhood Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor Cells by the Potent G-Quadruplex Interactive Agent S2T1-6OTD


 


Tarek Shalaby, André O. von Bueren, Marie-Louise Hürlimann, Giulio Fiaschetti, Deborah Castelletti, Tera Masayuki, Kazuo Nagasawa, Alexandre Arcaro, Ilian Jelesarov, Kazuo Shin-ya, Michael Grotzer
Mol. Cancer Ther. 2010, 9, 167-179. DOI:10.1158/1535-7163.MCT-09-0586


[76] Synthesis of (+)-Batzelladine K


 


Miyuki Sekine, Yumi Iijima, Osamu Iwamoto, Kazuo Nagasawa
Heterocycles 2010, 80, 395-408. DOI:10.3987/COM-09-S(S)36





[29] Recent Advances in Natural Products Synthesis Using Bifunctional Organocatalysts bearing a Hydrogen-bonding Donor Moiety


 


Minami Odagi, Kazuo Nagasawa
Asian J. Org. Chem. 2019, acceptedDOI:10.1002/ajoc.201900459


[28] i-Motif-binding ligands and their effects on the structure and biological functions of i-motif


 

   

Shadi Sedghi Masoud, Kazuo Nagasawa
Chem. Pharm. Bull. 201866, 1091-1103. DOI:10.1248/cpb.c18-00720


[27] Guanidine Organocatalysis for Enantioselective Carbon-Heteroatom Bond-forming Reactions


 


Keisuke Hosoya, Minami Odagi, Kazuo Nagasawa
Tetrahedron Lett. 2018, 8, 687-696. DOI:10.1016/j.tetlet.2017.12.058


[26] Synthetic studies of (23S,25R)-1,α,25-dihydroxyvitamin D3 26,23-lactone (calcitriol lactone) and its derivatives


 


Yusuke Akagi, Akiko Nagata, Minami Odagi, Kazuo Nagasawa
J. Steroid Biochem. Mol. Biol. 2018, 177, 240-246. DOI:10.1016/j.jsbmb.2017.07.017


[25] Total Synthesis of (+)-Linoxepin


 


Minami Odagi, Kota Furukori, Yoshiharu Yamamoto, Kazuo Nagasawa
Heterocycles 2017, 95, 116-126. DOI:10.3987/REV-16-SR(S)3


[24] A-Ring Synthons of 19-Nor Type Vitamin D Derivatives


 


Yusuke Akagi, Koji Yasui, Kazuo Nagasawa
J. Steroid. Biochem. Mol. Biol. 2017, 173 , 64-68. DOI:10.1016/j.jsbmb.2016.07.003


[23] 有機分子触媒を用いる不斉反応の開発と 天然物合成への応用


 


小田木陽、長澤和夫
月刊「化学工業」 2017, 68, **–**. DOI:No record


[22] Synthetic Studies of Oroidin-derived Pyrrole-imidazole Alkaloids


 


Makoto Iwata, Yuko Kamijoh, Kazuo Nagasawa
J. Synth. Org. Chem., Jpn. 2015, 73, 1092-1098. DOI:10.5059/yukigoseikyokaishi.73.1092


[21] Sequential stereodivergent organocatalysis and programmed organocascade


 


Yoshihiro Sohtome, Kazuo Nagasawa
Org. Biomol. Chem. 2014, 12, 1681-1685. DOI:10.1039/C3OB42310G


[20] 触媒的不斉酸化反応にも大活躍!–進化する環境にやさしい超原子価ヨウ素試薬


 


安井浩二、小田木陽、長澤和夫
月刊「化学」 2014, 69, 70–71. DOI:No record


[19] G-Quadruplexes as a Potential Therapeutic Target for Embryonal Tumors


 


Tarek Shalaby, Giulio Fiaschetti, Kazuo Nagasawa, Kazuo Shin-ya, Martin Baumgartner, Michael Grotzer
Molecules 2013, 18, 12500-12537. DOI:10.3390/molecules181012500


[18] Macrocyclic Polyoxazoles as G-Quadruplex Ligands


 


Keisuke Iida, Kazuo Nagasawa
Chem. Rec. 2013, 13, 539-548. DOI:10.1002/tcr.201300015


[17] Synthetic Approaches to Tetracyclic Pyrrole Imidazole Marine Alkaloids


 


Takuya Imaoka, Makoto Iwata, Takafumi Akimoto, Kazuo Nagasawa
Nat. Prod. Commun. 2013, 8, 961-964. DOI:no recored


[16] Dynamic asymmetric organocatalysis: cooperative effects of weak interactions and conformational flexibility in asymmetric organocatalysts


 


Yoshihiro Sohtome, Kazuo Nagasawa
Chem. Commum. 2012, 48, 7777-7789. DOI:10.1039/c2cc31846f


[15] Synthesis of saxitoxins


 


Osamu Iwamoto, Takafumi Akimoto, Kazuo Nagasawa
Pure Appl. Chem. 2012, 84, 1445-1453. DOI:10.1351/PAC-CON-11-09-10


[14] The Design of Chiral Double Hydrogen Bonding Networks and Their Applications to Catalytic Asymmetric Carbon-Carbon and Carbon-Oxygen Bond-Forming Reactions


 


Yoshihiro Sohtome, Kazuo Nagasawa
Synlett 2010, 1-22. DOI:10.1055/s-0029-1218542


[13] Synthetic Studies on Cyclic Guanidine Natural Products for the Elucidation of Their Controlling Mechanism of Protein-protein Interaction


 


Kazuo Nagasawa, Jun Shimokawa
J. Synth. Org. Chem., Jpn. 2006, 64, 539-547. DOI:10.5059/yukigoseikyokaishi.64.539


[12] Thalidomide as a multitarget drug and its application as a template for drug design


 


Yuichi Hashimoto, Aya Tanatani, Kazuo Nagasawa, Hiroyuki Miyachi
Drags Future 2004, 29, 383-391. DOI:10.1358/dof.2004.029.04.792298


[11] Synthesis of Marine Guanidine Alkaloids and Their Application Chemical/Biological Tools


 


Kazuo Nagasawa, Yuichi Hashimoto
Chem. Rec. 2003, 3, 201-2011. DOI:10.1002/tcr.10064


[10] Phase-Transfer Catalysts


 


長澤和夫
ファルマシア 2003, 39, 670. DOI:No record


[9] Total synthesis of marine cyclic guanidine compounds and development of novel guanidine type asymmetric organocatalysts


 


Kazuo Nagasawa
Yakugaku Zasshi 2003, 123, 387-398. DOI:No record


[8] サリドマイドの構造展開と活性拡張


 


長澤和夫、橋本祐一
細胞工学 2003, 22, 152-155. DOI:No record


[7] 古くて新しい高原子価ヨウ素試薬:IBX


 


長澤和夫
ファルマシア 2002, 38, 1096. DOI:No record


[6] ***


 


[5] Total Synthesis of Pinnatoxin A


 


Kazuo Nagasawa
J. Synth. Org. Chem., Jpn. 2000, 58, 877-886. DOI:10.5059/yukigoseikyokaishi.58.877


[4] ボランによるC-H結合活性化


 


長澤和夫
ファルマシア 2000, 36, 320. DOI:No record


[3] ***


 


[2] ***


 


[1] Palladium-Catalyzed Hydrogenolysis of Allylic Compounds with Formic Acid : Its Application to Organic Synthesis


 


Isao Shimizu, Masato Oshima, Kazuo Nagasawa, Jiro Tsuji, Tadakatsu Mandai
J. Synth. Org. Chem., Jpn. 1991, 49, 526-540. DOI:10.5059/yukigoseikyokaishi.49.526



[11] 有機分子触媒の開発と工業利用


 


グアニジン触媒を用いた不斉分子変換反応
細谷圭介、長澤和夫
シーエムシー出版 (2018), 秋山隆彦 編, pp. 126-139.


[10] Designed Molecular Space in Material Science and Catalysis


 


Design of the Chiral Enviroment for Asymmetric Acid-Base Catalysis
Yoshihiro Sohtome, Kazuo Nagasawa, Mikiko Sodeoka
Springer (2018), Seiji Shirakawa Ed., pp. 91-121.


[9] Guanidines as Reagents and Catalysts I


 


Conformationally Flexible Guanidine–(Thio)Urea Bifunctional Organocatalysts
Kazuo Nagasawa, Minami Odagi, Masaru Kato
Springer (2017), Philipp Selig Ed., pp. 157-178.


[8] 有機触媒の化学 モノづくりのパラダイムシフト


 


官能基複合型不斉グアニジン触媒と生理活性物質合成への応用
小田木陽、長澤和夫
化学同人 (2016), 日本化学会 編, pp. 118-127.


[7] 天然物合成で活躍した反応 実験のコツとポイント


 


IBX酸化
長澤和夫
化学同人 (2011), 有機合成化学協会 編, pp. **-**.


[6] 天然物全合成の最新動向


 


グアニジン系天然物サキシトキシン類の全合成
長澤和夫
シーエムシー出版 (2009), 北泰行 編, pp. **-**.


[5] 天然物の全合成 2000~2008(日本)


 


(+)-Batzelladine A
長澤和夫
化学同人 (2009), 有機合成化学協会 編, pp. 20-21.


[4] Superbases for Organic Synthesis: Guanidines, Amidines, Phosphazenes and Related Organocatalysts


 


Application of Organosuperbases to Total Synthesis
Kazuo Nagasawa
Wiley-VCH (2009), Tsutomu Ishikawa Ed., pp. 211-250.


[3] 進化を続ける有機触媒 有機合成を確信する第三の触媒


 


グアニジン型有機触媒
長澤和夫
化学同人 (2009), 丸岡啓二 編, pp. **-**.


[2] 天然物化学 –海洋生物編–


 


長澤和夫
アイピーシー (2008), 山村庄亮、長谷川宏司、木越英夫 編, pp. **-**.


[1] 有機分子触媒の新展開


 


長澤和夫
シーエムシー (2006), 柴崎正勝 編, pp. **-**.