Research

Synthesis of Biopolymer Using Hydrophobic-Soluble Support

We investigate toward a new methodology for synthesis of peptide and nucleic acid using hydrophobic-soluble support as a synthetic support and its application.
This soluble support highly disperses in less polar-reaction media and immediately aggregates in high polar solvent, resulting in integration of advantages having both solution- and solid-phase synthesis; high reactivity and rapid purification
1. These features have enabled us to synthesize several physiologically active peptides2 and oligonucleotide3 in high yield and large scale.


hP

References
1) Chem. Commun. 2002, 1766-1767. Chem. Commun. 2008, 1816−1818. Langmuir, 2009, 25, 11043−11047. Tetrahedron, 2009, 65, 8014−8020.
2) Chem. Commun. 2010, 46, 8219−8221. Bioorg. Med. Chem. Lett. 2011, 21, 4476−4479. J.Org. Chem. 2013, 78, 320-327.
Org. Lett., 2013, 15, 1155-1157.  Tetrahedron, 2014, 70, 7774-7779. Org. Lett., 2014, 16, 6448-6451.
3) Chem. Eur. J., 2013, 19, 8615-8620. Chem. Lett., 2014, 43, 1251-1253.









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