Research
Synthesis of Biopolymer Using
Hydrophobic-Soluble Support
We investigate toward a new methodology for synthesis
of peptide and nucleic acid using hydrophobic-soluble
support as a synthetic support and its application.
This soluble support highly disperses in less
polar-reaction media and immediately aggregates in high
polar solvent, resulting in integration of advantages
having both solution- and solid-phase synthesis; high
reactivity and rapid purification1.
These features have enabled us to synthesize several
physiologically active peptides2
and oligonucleotide3
in high yield and large scale.
References
1) Chem. Commun. 2002, 1766-1767. Chem. Commun. 2008, 1816−1818. Langmuir, 2009, 25, 11043−11047. Tetrahedron, 2009, 65, 8014−8020.
2) Chem. Commun. 2010, 46, 8219−8221. Bioorg. Med. Chem. Lett. 2011, 21, 4476−4479. J.Org. Chem. 2013, 78, 320-327. Org. Lett., 2013, 15, 1155-1157. Tetrahedron, 2014, 70, 7774-7779. Org. Lett., 2014, 16, 6448-6451.
3) Chem. Eur. J., 2013, 19, 8615-8620. Chem. Lett., 2014, 43, 1251-1253.