Original papers

 2017

Wakamatsu, H.; Okada, Y.; Sugai, M.; Hussaini, S. R.; Chiba, K.
Photo-Triggered Fluorometric Hydrophobic Benzyl Alcohol for Soluble Tag-Assisted Liquid-Phase Peptide Synthesis
Asian. J. Org. Chem. 2017, accepted.
2017-6

Okada, Y.; Asama, H.; Wakamatsu, H.; Chiba, K.; Kamiya, H.
Hydrophobic Magnetic Nanoparticle-Assisted One-Pot Liquid Phase Peptide Synthesis
Eur. J. Org. Chem. 2017, accepted.
2017-5

Ozaki, A.; Yamaguchi, Y.; Okada, Y.; Chiba, K.
Bidirectinal Access to Radical Cation Diels-Alder Reactions by Electrocatalysis
Chem. Electro. Chem. 2017, 4(8), 1852-1855.
2017-4

Chiba, K.; Okada, Y.
Electron-transfer-induced morecular reactions: Electrode processes in organic synthesis
Current opinion in Electrochemistry 2017, 2:53-59.
2017-1

Imada, Y.; Yamaguchi, Y.; Shida, N.;Okada, Y.; Chiba, K.
Entropic Electrolytes fpr Anodic Cycloaddiotions of Unactivated Alkene Nucleophiles
Chem. Comm. 2017, 53, 3960-3963.
2017-1


Shoji, T.; Kim, S.; Chiba, K.
New method for the synthesis and 4’-nitrogen-based diversification of azanucleosides via anodic oxidation in lithium perchlorate-nitroalkane medium
Angew. Chem. Int. Ed. 2017, 56, 4011-4014.
2017-1

 2016

Okada, I.; Fukuda, T.; Kuroda, Y.; Noguchi, K.; Chiba, K.; Kitano, Y.
Direct Synthesis of Bis(alkylamino)maleonitriles from Alcohols and TMSCN with Bi(OTf)3
Synthesis 2016, 48, A-F..
2016-10


Okada, Y.; Sugai, M.; Chiba, K.
Hydrogen-Bonding-Induced Fluorescence: Water-Soluble and Polarity-Independent Solvatochromic Fluorophores
J. Org. Chem. 2016, 81, 10922-10929.
2016-9 

Takahashi, M.; Handa, A.; Yamaguchi, Y.; Kodama, R.; Chiba, K.
Anodic oxidative modification of egg white for heat treatment
J. Agric. Food Chem. 2016, 64, 6503-6507.
2016-8

Fukuda, T.; Wagatsuma, H.; Kominami, Y.; Nogata, Y.; Yoshimura, E.; Chiba, K.; Kitano, Y.
Anti-barnacle activity of isocyanides derived from amino acids
Chem. Biodivers. 2016, 13, 1502-1510.
2016-7 


Okada, Y.; Yamaguchi, Y.; Ozaki, A.; Chiba, K.
Aromatic “Redox Tag”-Assisted Diels-Alder Reactions by Electrocatalysis
Chem. Sci. 2016, 7, 6383-6393
.
2016-6


千葉 一裕
有機電解法の進展とペプチドおよび核酸誘導体の化学合成への応用
化学と生物 2016, 54, 478-483.

2016-5


Okada, Y.; Chiba, K.
Soluble-Support-Assisted Liquid-Phase Peptide Synthesis.
J. Synth. Org. Chem. Jpn. 2016, 74, 588–598.

2016-4


Takahashi, M.; Handa, A.; Kodama, R.; Chiba, K.
Anodic oxidative disulfide bond formation in egg protein
Electroanalysis 2016, 28, 2737-2742.

2016-3


Shoji, T.; Haraya, S.; Kim, S.; Chiba, K.
Development of anodic modification reaction of N-acryloyl-proline derivatives using lithium perchlorate-nitromethane system
Electrochim. Acta 2016, 200, 290-295.




Matsuno, Y.; Shoji, T.; Kim, S.; Chiba, K.
Synthetic Method for Oligonucleotide Block by Using Alkyl-Chain-Soluble Support
Org. Lett. 2016, 18, 800-803.
2016-1

 2015

Okada, Y.; Wakamatsu, H.; Sugai, M.; Kauppinen, E. I.; Chiba, K.
Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis
Org. Lett. 2015, 17, 4264-4267.



Matsumoto, E.; Fujita, Y.; Okada, Y.; Kauppinen, E. I.; Kamiya, H.; Chiba, K.
Hydrophobic benzyl amines as supports for liquid-phase C-terminal amidated peptide synthesis: application to the preparation of ABT-510
J. Pept. Sci. 2015,
21, 691-695.



 2014

Okada, Y.; Hosoya, S.; Suzuki, H.; Chiba, K.
Total Synthesis of Elastin Peptide using High Pressure-Liquid Phase Synthesis Assisted by a Soluble Tag Strategy,
Org. Lett. 2014, 16, 6448-6451.

Total Synthesis of Elastin Peptide

Shoji, T.; Kim, S.; Yamamoto, K.; Kawai, T.; Okada, Y.; Chiba, K.
Anodic Substitution Reaction of Proline Derivatives using the 2,4,6-Trimethoxyphenyl Leaving Group,
Org. Lett. 2014, 16, 6404-6407.


Aoki, K.; Maeda, M.; Nakae, T.; Okada, Y.; Ohya, K.; Chiba, K.
A disulfide bond-replacement strategy enables the efficient design of artificial therapeutic peptides,
Tetrahedron 2014, 70, 7774-7779.

aoki_tetrahedron

Takahashi, M.; Okada, Y.; Kitano, Y.; Chiba, K.
Phase-transfer-mediated electrochemical reaction: anodic disulfide bond formation under biphasic condition,
Tetrahedron Lett. 2014,
55, 3622-3624.

2014TL


Shoji, T.; Kim, S.; Chiba, K.
Synthesis of Conjugated Oligonucleotide in Solution-Phase Using Alkyl-Chain-Soluble Support,
Chemistry Lett. 2014, 43, 1251-1253
.

chemlett


Abe, R.; Shimizu, S.; Yasuda, K.; Sugai, M.; Okada, Y.; Chiba, K.; Akao, M.; Kumagai, H.; Kumagai, H.
Evaluation of Reduced Allergenicity of Deamidated Gliadin in a Mouse Model of Wheat-Gliadin Allergy Using an Antibody Prepared by a Peptide Containing Three Epitopes,
J. Agric. Food Chem. 2014, 62, 2845-2852.

jagri2014


Mihara, K.; Okada, I.; Chiba, K.; Kitano, Y.
Facile Synthesis of N-Substituted Amides from Alkenes and Amides by a Brønsted Acid Mediated Electrophilic Addition Reaction,
Synthesis 2014, 46, 1455-1462.

synthesis


Okada, Y.; Shimada, K.; Kitano, Y.; Chiba, K.
Short Step Anodic Access to Emissive RNA Homonucleosides,
Eur. J. Org. Chem. 2014, 1371-1375. Selected as COVER PICTURE!

ejcocoverpic     ejoc.201301604


Akutagawa, I.; Akiyama, Y.; Takahashi, Y.; Iijima, M.; Okada, Y.; Kamiya, H.; Chiba, K.
Toward Continuous LC-MS Analysis: Surface Modification of Magnetic Microparticles with TiO2 for Phosphate Adsorption,
Biosci. Biotechnol. Biochem. 2014, 78, 748-754.

akutabbb

2013

Fujiwara, S.; Akima, C.; Nogata, Y.; Yoshimura, E.; Chiba, K.; Kitano, Y.
Bio-organic and anti-barnacle studies of fluorescence-labeled probe compounds against cyprids of barnacles,
J. Exp. Mar. Biol. Ecol. 2013, 445, 88-92.

JEMBE

Kim, S.; Shoji, T.; Kitano, Y.; Chiba, K.
Electrochemical Synthesis of Azanucleotide Derivatives using Lithium Perchlorate-Nitromethane System,
Chem. Commun. 2013, 49, 6525-6527.
 Chem.
                      Commun

Kim, S.; Matsumoto, M.; Chiba, K.
Liquid-Phase RNA Synthesis by Using Alkyl-Chain-Soluble Support,
Chem. Eur. J.2013, 19, 8615-8620.
Liquid-Phase RNA Synthesis by Using
                      Alkyl-Chain-Soluble Support

Kamimura, K.; Okada, Y.; Chiba, K.
Investigation of the Pathway for Intramolecular Electron Transfer in Anodic [2 + 2] Cycloaddition Reactions,
Electrochemistry 2013, 81, 377-379.
Electrochemistry, 2013,
                  81, 377-379.

Yamaguchi, Y.; Okada, Y.; Chiba, K.
Cyclic Voltammetric Studies on Electrocatalytic Intermolecular [2 + 2] Cycloaddition Reactions in Lithium Perchlorate / Nitromethane Electrolyte Solution,
Electrochemistry 2013, 81, 331-333.    
Electrochemistry, 2013, 81, 331-333.

Fujita, Y.; Fujita, S.; Okada, Y.; Chiba, K.
Soluble Tag-Assisted Peptide Head-to-Tail Cyclization: Total Synthesis of Mahafacyclin B,
Org. Lett. 2013, 15, 1155-1157.
  Org. Lett.
                  2013, 15, 1155-1157.

Okada, I.; Chiba, K.; Kitano, Y.
Facile Synthesis of N-Substituted Amides from Alcohols and Amides,
Synthesis 2013, 45, 1069-1075.
SYNTHESIS 2013, 45, 1069–1075

Yamaguchi, Y.; Okada, Y.; Chiba, K.
Understanding the Reactivity of Enol Ether Radical Cations: Investigation in Anodic Four-Membered Carbon Ring Formation,
J. Org. Chem. 2013, 78, 2626-2638.
J.
                  Org. Chem. 2013, 78, 2626-2638.

Kitada, S.; Fujita, S.; Okada, Y.; Kim, S.; Chiba, K.
Total synthesis of a-conotoxin MII using a soluble-tag-assisted method,
Tetrahedron 2013, 69, 2555-2559.
  Tetrahedron, 2013, 69, 2555-2559.

Okada, Y.; Suzuki, H.; Nakae, T.; Fujita, S.; Abe, H.; Nagano, K.; Yamada, T.; Ebata, N.; Kim, S.; Chiba, K.
Tag-Assisted Liquid-Phase Peptide Synthesis Using Hydrophobic Benzyl Alcohols as Supports,
J. Org. Chem. 2013, 78, 320-327.


J. Org. Chem. 2013, 78, 320-327.


2012-2009


Kitada, S.; Takahashi, M.; Yamaguchi, Y.; Okada, Y.; Chiba, K.
Soluble-support-assisted Electrochemical Reactions: Application to Anodic Disulfide Bond Formation,
Org. Lett.
2012, 14, 5960-5963.
Okada, Y.; Chiba, K.
Intermolecular Olefin Cross-Metathesis Initiated by the Umpolung of Enol Ethers,
Journal of Synthetic Organic Chemistry, Japan. 2012, 70, 701-710.
Okada, Y.; Kamimura, K.; Chiba K.
Cycloalkane-based thermomorphic systems for organic electrochemistry:an application to Kolbe-coupling,
Tetrahedron. 2012, 68, 5857-5862.
Kim, S.; Hirose, K.; Uematsu, J.; Mikami, Y.; Chiba,K.
Electrochemically Active Cross-Linking Reaction for Fluorescent Labeling of Aliphatic Alkenes,
Chem. Eur. J.
2012, 18, 6284-6288.
Okada, Y.; Yamaguchi, Y.; Chiba, K.
Efficient Intermolecular Carbon-Carbon Bond Formation Reactions Assisted by Surface-Condensed Electrodes,
Eur. J. Org. Chem. 2012, 243-246.
Kim, S.; Ikuhisa, N.; Chiba, K.
A Cycloalkane-based Thermomorphic System for Organocatalytic Cyclopropanation Using Ammonium Ylide,
Chemistry Letters. 2011, 40, 1077–1078.
Okada, I.; Kitano, Y.
One-Pot Synthesis of Isocyanides from Alcohols,
Synthesis.
2011, 24, 3997–4002.
Okada, Y.; Yoshioka, T.; Koike, M.; Chiba, K.
Heterogeneous continuous flow synthetic system using cyclohexane-based multiphase electrolyte solutions,
Tetrahedron Lett. 2011, 52, 4690–4693.
Kobayashi, G.; Saito, T.; Kitano, Y.
A Novel Method for Preparing Isocyanides from N-Substituted Formamides with Chlorophosphate Compounds,
Synthesis. 2011, 20, 3225–3234.
Kitada, S.; Fujita, S.; Okada, Y.; Kim, S.; Chiba, K.
Hydrophobic tag-assisted liquid-phase synthesis of a growth hormone-inhibiting peptide somatostatin,
Bioorg. Med. Chem. Lett. 2011, 21, 4476–4479.
Akiyama, Y.; Takahashi, Y.; Akutagawa, I.; Ono, A.; Morishima, K.; Chiba, K.
Demonstration of on-line desalination for LC–MS using phosphate adsorption onto TiO2-coated magnetic microparticles within a microchannel,
International Journal of Mass Spectrometry. 2011, 306, 37–43.
Okada, Y.; Nishimoto, A.; Akaba, R.; Chiba, K.
Electron Transfer-induced Intermolecular [2 + 2] Cycloaddition Reactions Based on the Aromatic “Redox Tag” Strategy,
J. Org. Chem. 2011, 76, 3470–3476.
Nishimoto, K.; Okada, Y.; Kim, S.; Chiba, K.
Rate acceleration of Diels–Alder reactions utilizing a fluorous micellar system in water,
Electrochim Acta
, 2011, 28, 10626-10631.
Kitano, Y.; Akima, C.; Yoshimura, E.; Nogata, Y.
Anti-barnacle activity of novel simple alkyl isocyanides derived from citronellol,
Biofouling
,2011, 27, 201–205.
Okada, Y.; Chiba, K.
Electron transfer-induced four-membered cyclic intermediate formation: Olefin cross-coupling vs. olefin cross-metathesis,
Electrochimica Acta,2011, 56, 1037–1042.
Tana, G.; Kitada, S.; Fujita, S.; Okada, Y.; Kim, S.; Chiba, K.
A practical solution-phase synthesis of an antagonistic peptide of TNF-a based on hydrophobic tag strategy,
Chem. Commun. 2010, 46, 8219–8221.
Okada,Y.; Chiba,K.
Continuous Electrochemical Synthetic System Using a Multiphase Electrolyte Solution,
Electrochimica Acta,2010,55,4112-4119.
Mizoguchi, T.; Nagata, K.; Kitsunai, M.; Hirose, K.; Hirasawa, A.; Chiba, K.
Construction of Cold-triggered/Heat-destroyed Emulsions for Use as a Practical Cold-Storage Thermal History Indicator,
J. Sci. Food Agric. 2009, 89, 1453-1461.
Okada, Y.; Akaba, R.; Chiba, K.
Electrocatalytic Formal [2+2] Cycloaddition Reactions between Anodically Activated Aliphatic Enol Ethers and Unactivated Olefins Possessing an Alkoxyphenyl Group,
Org. Lett. 2009, 11, 1033-1035.
Chiba, K.; Kim, S. 
Anodic Carbon-Carbon Bond Formation in Lithium Perchlorate/Nitromethane Electrolyte Solution,
Electrochemistry, 2009, 77, 21-29.
Chiba, K.; Sugihara, M.; Yoshida,K.; Mikami, M.; Kim, S.
Synthesis of Hydrophobic Phase-Tagged Prolyl Peptides Featuring Rapid Reac-tion/Separation,
Tetrahedron, 2009, 65, 8014-8020.
Okada,Y.; Akaba,R.; Chiba,K.
EC-backward-E Electrochemistry Sup-ported by an Alkoxyphenyl Group,
Tetrahedron Letters
, 2009, 50, 5413-5416.
Kim, S.; Chiba, K.
Solution-Phase Chemical Processes Featuring Facile Mul-ti-Step Reactions,
Journal of Synthetic Organic Chemistry, 2009, 67, 809-819.
Iijima, M.; Mikami, Y.; Yoshioka, T.; Kim, S.; Kamiya, H.; Chiba, K.
Rapid Magnetic Catch-and-Release Purification by Hydrophobic Interactions,
Langmuir, 2009, 25, 11043-11047.

Publication before 2009

Books


小路 貴生, 金 承鶴, 千葉 一裕
有機電解合成による人工核酸の機能拡張
Electrochemistry Vol. 83 (2015) No. 6 p. 467-471
Yohei Okada and Kazuhiro Chiba.
Biphasic Electrolytic System, Electrochemical Chain Reaction,
Encyclopedia of Applied Electrochemistry Savinell, R. F., Ota, K., Kreysa, G.,(eds).; Springer: Heidelberg, accepted. 
Yohei Okada and Kazuhiro Chiba (2012).
Electron Transfer Catalyzed Reaction,
Organic Electrochemistry, 5th ed.; Hammerich, O., Speiser, B.,(eds).; Taylor & Francis: New York, accepted.
Yohei Okada and Kazuhiro Chiba (2012).
Cyclohexane-Based Liquid-Biphasic Systems for Organic Electrochemistry,
Developments in Electrochemistry, Jang H. Chun.,(ed).; InTech, Chapter 4, 79-100, DOI:10.5772/53362.
Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba,
Practical Intramolecular Disulfide Formation Based on Hydrophobic Tag Strategy,
Peptide Science, 139-140, 2012, K. Sakaguchi,(eds). 
千葉一裕、
「疎水性タグを用いた液相ペプチド合成」
遺伝子医学MOOK21号特集「最新ペプチド合成技術と創薬研究への応用」編集 木曽良明 株式会社メディカルドゥ 2012, p.61-65. 
Kazuhiro Chiba and Yohei Okada (2012).
Electron-Transfer-Induced Intermolecular [2 + 2] Cycloaddition Reactions Assisted by Aromatic “Redox Tag”,
Recent Trend in Electrochemical Science and Technology, Ujjal Kumar Sur,(ed).; InTech, 91–106 DOI: 10.5772/33707.
千葉一裕、
「相溶溶液反応」、
有機合成化学協会誌、2009, 67, p 848 


Publication before 2009








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