Original papers


Imada, Y.; Röckl, J. L.; Wiebe, A.; Gieshoff, T.; Chiba, K.; Franke, R.; Waldvogel, S. R.
Metal- and Reagent-Free Dehydrogenative Benzyl-Aryl Cross-Coupling by Anodic Activation in 1,1,1,3,3,3-Hexafluoropropan-2-ol
Angew. Chem. Int. Ed. 2018, accepted (Very Important Paper)

Kuroda, Y.; Hasegawa, K.; Noguchi, K.; Chiba, K.; Hasumi, K.; Kitano, Y.
Confirmation of the absolute configuration of Stachybotrin C using single-crystal X-ray diffraction analysis of its 4-bromobenzyl ether derivative
The Journal of Antibiotics 2018, accepted

Shimizu, R.; Okada, Y.; Chiba, K.
Stepwise radical cation Diels–Alder reaction via multiple pathways
Beilstein J. Org. Chem. 2018, accepted

Imada, Y.; Okada, Y.; Chiba, K.
Investigating radical cation chain processes in the electrocatalytic Diels–Alder reaction
Beilstein J. Org. Chem. 2018, 14, 642-647

Inoue, Y.; Takashima, S.; Nogata, Y.; Yoshimura, E.; Chiba, K.; Kitano, Y.;
Isocyanides Derived from α,α-Disubstituted Amino Acids: Synthesis and Antifouling Activity Assessment
Chemistry & Biodiversity 2018, accepted


Ogami, K.; Okada, Y.; Chiba, K.
A Pot-economical Liquid-phase Peptide Nucleic Acid Synthesis Enabled by a Soluble Tag-assisted Method
Chem. lett. 2018, 47, 138-140

Okada, Y.; Chiba, K.
Redox-Tag Processes: Intramolecular Electron Transfer and Its Broad Relationship to Redox Reactions in General
Chem. Review 2017, press

Fujita, Y.; Seekaki, P.; Ogata, N.; Chiba, K.
Physiological effects of a novel artificially synthesized antimalarial cyclic peptide: Mahafacyclin B
PLOS ONE 2017, 12(11)

Okada, Y.; Chiba, K.
Redox-Tag Processes: Intramolecular Electron Transfer and Its Broad Relationship to Redox Reactions in General
Chem. Review 2017, press

Wakamatsu, H.; Handa, A.; Chiba, K.
Observations using Phosphorus-31 Nuclear Magnetic Resonance (31P-NMR) of Structural Changes in Freeze-Thawed Hen Egg Yolk
Food Chemistry 2018, 244, 169-176.

Wakamatsu, H.; Okada, Y.; Sugai, M.; Hussaini, S. R.; Chiba, K.
Photo-Triggered Fluorometric Hydrophobic Benzyl Alcohol for Soluble Tag-Assisted Liquid-Phase Peptide Synthesis
Asian. J. Org. Chem. 2017, accepted. (selected as COVER PICTURE)

Okada, Y.; Asama, H.; Wakamatsu, H.; Chiba, K.; Kamiya, H.
Hydrophobic Magnetic Nanoparticle-Assisted One-Pot Liquid Phase Peptide Synthesis
Eur. J. Org. Chem. 2017, accepted. (selected as COVER PICTURE)

Ozaki, A.; Yamaguchi, Y.; Okada, Y.; Chiba, K.
Bidirectinal Access to Radical Cation Diels-Alder Reactions by Electrocatalysis
Chem. Electro. Chem. 2017, 4(8), 1852-1855.

Chiba, K.; Okada, Y.
Electron-transfer-induced morecular reactions: Electrode processes in organic synthesis
Current opinion in Electrochemistry 2017, 2:53-59.

Imada, Y.; Yamaguchi, Y.; Shida, N.; Okada, Y.; Chiba, K.
Entropic Electrolytes fpr Anodic Cycloaddiotions of Unactivated Alkene Nucleophiles
Chem. Comm. 2017, 53, 3960-3963.

Shoji, T.; Kim, S.; Chiba, K.
New method for the synthesis and 4’-nitrogen-based diversification of azanucleosides via anodic oxidation in lithium perchlorate-nitroalkane medium
Angew. Chem. Int. Ed. 2017, 56, 4011-4014.


Okada, I.; Fukuda, T.; Kuroda, Y.; Noguchi, K.; Chiba, K.; Kitano, Y.
Direct Synthesis of Bis(alkylamino)maleonitriles from Alcohols and TMSCN with Bi(OTf)3
Synthesis 2016, 48, A-F..

Okada, Y.; Sugai, M.; Chiba, K.
Hydrogen-Bonding-Induced Fluorescence: Water-Soluble and Polarity-Independent Solvatochromic Fluorophores
J. Org. Chem. 2016, 81, 10922-10929.

Takahashi, M.; Handa, A.; Yamaguchi, Y.; Kodama, R.; Chiba, K.
Anodic oxidative modification of egg white for heat treatment
J. Agric. Food Chem. 2016, 64, 6503-6507.

Fukuda, T.; Wagatsuma, H.; Kominami, Y.; Nogata, Y.; Yoshimura, E.; Chiba, K.; Kitano, Y.
Anti-barnacle activity of isocyanides derived from amino acids
Chem. Biodivers. 2016, 13, 1502-1510.

Okada, Y.; Yamaguchi, Y.; Ozaki, A.; Chiba, K.
Aromatic “Redox Tag”-Assisted Diels-Alder Reactions by Electrocatalysis
Chem. Sci. 2016, 7, 6383-6393

千葉 一裕
化学と生物 2016, 54, 478-483.


Okada, Y.; Chiba, K.
Soluble-Support-Assisted Liquid-Phase Peptide Synthesis.
J. Synth. Org. Chem. Jpn. 2016, 74, 588–598.


Takahashi, M.; Handa, A.; Kodama, R.; Chiba, K.
Anodic oxidative disulfide bond formation in egg protein
Electroanalysis 2016, 28, 2737-2742.


Shoji, T.; Haraya, S.; Kim, S.; Chiba, K.
Development of anodic modification reaction of N-acryloyl-proline derivatives using lithium perchlorate-nitromethane system
Electrochim. Acta 2016, 200, 290-295.

Matsuno, Y.; Shoji, T.; Kim, S.; Chiba, K.
Synthetic Method for Oligonucleotide Block by Using Alkyl-Chain-Soluble Support
Org. Lett. 2016, 18, 800-803.


Okada, Y.; Wakamatsu, H.; Sugai, M.; Kauppinen, E. I.; Chiba, K.
Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis
Org. Lett. 2015, 17, 4264-4267.

Matsumoto, E.; Fujita, Y.; Okada, Y.; Kauppinen, E. I.; Kamiya, H.; Chiba, K.
Hydrophobic benzyl amines as supports for liquid-phase C-terminal amidated peptide synthesis: application to the preparation of ABT-510
J. Pept. Sci. 2015,
21, 691-695.


Okada, Y.; Hosoya, S.; Suzuki, H.; Chiba, K.
Total Synthesis of Elastin Peptide using High Pressure-Liquid Phase Synthesis Assisted by a Soluble Tag Strategy,
Org. Lett. 2014, 16, 6448-6451.

Total Synthesis of Elastin Peptide

Shoji, T.; Kim, S.; Yamamoto, K.; Kawai, T.; Okada, Y.; Chiba, K.
Anodic Substitution Reaction of Proline Derivatives using the 2,4,6-Trimethoxyphenyl Leaving Group,
Org. Lett. 2014, 16, 6404-6407.

Aoki, K.; Maeda, M.; Nakae, T.; Okada, Y.; Ohya, K.; Chiba, K.
A disulfide bond-replacement strategy enables the efficient design of artificial therapeutic peptides,
Tetrahedron 2014, 70, 7774-7779.


Takahashi, M.; Okada, Y.; Kitano, Y.; Chiba, K.
Phase-transfer-mediated electrochemical reaction: anodic disulfide bond formation under biphasic condition,
Tetrahedron Lett. 2014,
55, 3622-3624.


Shoji, T.; Kim, S.; Chiba, K.
Synthesis of Conjugated Oligonucleotide in Solution-Phase Using Alkyl-Chain-Soluble Support,
Chemistry Lett. 2014, 43, 1251-1253


Abe, R.; Shimizu, S.; Yasuda, K.; Sugai, M.; Okada, Y.; Chiba, K.; Akao, M.; Kumagai, H.; Kumagai, H.
Evaluation of Reduced Allergenicity of Deamidated Gliadin in a Mouse Model of Wheat-Gliadin Allergy Using an Antibody Prepared by a Peptide Containing Three Epitopes,
J. Agric. Food Chem. 2014, 62, 2845-2852.


Mihara, K.; Okada, I.; Chiba, K.; Kitano, Y.
Facile Synthesis of N-Substituted Amides from Alkenes and Amides by a Brønsted Acid Mediated Electrophilic Addition Reaction,
Synthesis 2014, 46, 1455-1462.


Okada, Y.; Shimada, K.; Kitano, Y.; Chiba, K.
Short Step Anodic Access to Emissive RNA Homonucleosides,
Eur. J. Org. Chem. 2014, 1371-1375. Selected as COVER PICTURE!

ejcocoverpic     ejoc.201301604

Akutagawa, I.; Akiyama, Y.; Takahashi, Y.; Iijima, M.; Okada, Y.; Kamiya, H.; Chiba, K.
Toward Continuous LC-MS Analysis: Surface Modification of Magnetic Microparticles with TiO2 for Phosphate Adsorption,
Biosci. Biotechnol. Biochem. 2014, 78, 748-754.



Fujiwara, S.; Akima, C.; Nogata, Y.; Yoshimura, E.; Chiba, K.; Kitano, Y.
Bio-organic and anti-barnacle studies of fluorescence-labeled probe compounds against cyprids of barnacles,
J. Exp. Mar. Biol. Ecol. 2013, 445, 88-92.


Kim, S.; Shoji, T.; Kitano, Y.; Chiba, K.
Electrochemical Synthesis of Azanucleotide Derivatives using Lithium Perchlorate-Nitromethane System,
Chem. Commun. 2013, 49, 6525-6527.

Kim, S.; Matsumoto, M.; Chiba, K.
Liquid-Phase RNA Synthesis by Using Alkyl-Chain-Soluble Support,
Chem. Eur. J.2013, 19, 8615-8620.
Liquid-Phase RNA Synthesis by Using
                      Alkyl-Chain-Soluble Support

Kamimura, K.; Okada, Y.; Chiba, K.
Investigation of the Pathway for Intramolecular Electron Transfer in Anodic [2 + 2] Cycloaddition Reactions,
Electrochemistry 2013, 81, 377-379.
Electrochemistry, 2013,
                  81, 377-379.

Yamaguchi, Y.; Okada, Y.; Chiba, K.
Cyclic Voltammetric Studies on Electrocatalytic Intermolecular [2 + 2] Cycloaddition Reactions in Lithium Perchlorate / Nitromethane Electrolyte Solution,
Electrochemistry 2013, 81, 331-333.    
Electrochemistry, 2013, 81, 331-333.

Fujita, Y.; Fujita, S.; Okada, Y.; Chiba, K.
Soluble Tag-Assisted Peptide Head-to-Tail Cyclization: Total Synthesis of Mahafacyclin B,
Org. Lett. 2013, 15, 1155-1157.
  Org. Lett.
                  2013, 15, 1155-1157.

Okada, I.; Chiba, K.; Kitano, Y.
Facile Synthesis of N-Substituted Amides from Alcohols and Amides,
Synthesis 2013, 45, 1069-1075.
SYNTHESIS 2013, 45, 1069–1075

Yamaguchi, Y.; Okada, Y.; Chiba, K.
Understanding the Reactivity of Enol Ether Radical Cations: Investigation in Anodic Four-Membered Carbon Ring Formation,
J. Org. Chem. 2013, 78, 2626-2638.
                  Org. Chem. 2013, 78, 2626-2638.

Kitada, S.; Fujita, S.; Okada, Y.; Kim, S.; Chiba, K.
Total synthesis of a-conotoxin MII using a soluble-tag-assisted method,
Tetrahedron 2013, 69, 2555-2559.
  Tetrahedron, 2013, 69, 2555-2559.

Okada, Y.; Suzuki, H.; Nakae, T.; Fujita, S.; Abe, H.; Nagano, K.; Yamada, T.; Ebata, N.; Kim, S.; Chiba, K.
Tag-Assisted Liquid-Phase Peptide Synthesis Using Hydrophobic Benzyl Alcohols as Supports,
J. Org. Chem. 2013, 78, 320-327.

J. Org. Chem. 2013, 78, 320-327.


Kitada, S.; Takahashi, M.; Yamaguchi, Y.; Okada, Y.; Chiba, K.
Soluble-support-assisted Electrochemical Reactions: Application to Anodic Disulfide Bond Formation,
Org. Lett.
2012, 14, 5960-5963.
Okada, Y.; Chiba, K.
Intermolecular Olefin Cross-Metathesis Initiated by the Umpolung of Enol Ethers,
Journal of Synthetic Organic Chemistry, Japan. 2012, 70, 701-710.
Okada, Y.; Kamimura, K.; Chiba K.
Cycloalkane-based thermomorphic systems for organic electrochemistry:an application to Kolbe-coupling,
Tetrahedron. 2012, 68, 5857-5862.
Kim, S.; Hirose, K.; Uematsu, J.; Mikami, Y.; Chiba,K.
Electrochemically Active Cross-Linking Reaction for Fluorescent Labeling of Aliphatic Alkenes,
Chem. Eur. J.
2012, 18, 6284-6288.
Okada, Y.; Yamaguchi, Y.; Chiba, K.
Efficient Intermolecular Carbon-Carbon Bond Formation Reactions Assisted by Surface-Condensed Electrodes,
Eur. J. Org. Chem. 2012, 243-246.
Kim, S.; Ikuhisa, N.; Chiba, K.
A Cycloalkane-based Thermomorphic System for Organocatalytic Cyclopropanation Using Ammonium Ylide,
Chemistry Letters. 2011, 40, 1077–1078.
Okada, I.; Kitano, Y.
One-Pot Synthesis of Isocyanides from Alcohols,
2011, 24, 3997–4002.
Okada, Y.; Yoshioka, T.; Koike, M.; Chiba, K.
Heterogeneous continuous flow synthetic system using cyclohexane-based multiphase electrolyte solutions,
Tetrahedron Lett. 2011, 52, 4690–4693.
Kobayashi, G.; Saito, T.; Kitano, Y.
A Novel Method for Preparing Isocyanides from N-Substituted Formamides with Chlorophosphate Compounds,
Synthesis. 2011, 20, 3225–3234.
Kitada, S.; Fujita, S.; Okada, Y.; Kim, S.; Chiba, K.
Hydrophobic tag-assisted liquid-phase synthesis of a growth hormone-inhibiting peptide somatostatin,
Bioorg. Med. Chem. Lett. 2011, 21, 4476–4479.
Akiyama, Y.; Takahashi, Y.; Akutagawa, I.; Ono, A.; Morishima, K.; Chiba, K.
Demonstration of on-line desalination for LC–MS using phosphate adsorption onto TiO2-coated magnetic microparticles within a microchannel,
International Journal of Mass Spectrometry. 2011, 306, 37–43.
Okada, Y.; Nishimoto, A.; Akaba, R.; Chiba, K.
Electron Transfer-induced Intermolecular [2 + 2] Cycloaddition Reactions Based on the Aromatic “Redox Tag” Strategy,
J. Org. Chem. 2011, 76, 3470–3476.
Nishimoto, K.; Okada, Y.; Kim, S.; Chiba, K.
Rate acceleration of Diels–Alder reactions utilizing a fluorous micellar system in water,
Electrochim Acta
, 2011, 28, 10626-10631.
Kitano, Y.; Akima, C.; Yoshimura, E.; Nogata, Y.
Anti-barnacle activity of novel simple alkyl isocyanides derived from citronellol,
,2011, 27, 201–205.
Okada, Y.; Chiba, K.
Electron transfer-induced four-membered cyclic intermediate formation: Olefin cross-coupling vs. olefin cross-metathesis,
Electrochimica Acta,2011, 56, 1037–1042.
Tana, G.; Kitada, S.; Fujita, S.; Okada, Y.; Kim, S.; Chiba, K.
A practical solution-phase synthesis of an antagonistic peptide of TNF-a based on hydrophobic tag strategy,
Chem. Commun. 2010, 46, 8219–8221.
Okada,Y.; Chiba,K.
Continuous Electrochemical Synthetic System Using a Multiphase Electrolyte Solution,
Electrochimica Acta,2010,55,4112-4119.
Mizoguchi, T.; Nagata, K.; Kitsunai, M.; Hirose, K.; Hirasawa, A.; Chiba, K.
Construction of Cold-triggered/Heat-destroyed Emulsions for Use as a Practical Cold-Storage Thermal History Indicator,
J. Sci. Food Agric. 2009, 89, 1453-1461.
Okada, Y.; Akaba, R.; Chiba, K.
Electrocatalytic Formal [2+2] Cycloaddition Reactions between Anodically Activated Aliphatic Enol Ethers and Unactivated Olefins Possessing an Alkoxyphenyl Group,
Org. Lett. 2009, 11, 1033-1035.
Chiba, K.; Kim, S. 
Anodic Carbon-Carbon Bond Formation in Lithium Perchlorate/Nitromethane Electrolyte Solution,
Electrochemistry, 2009, 77, 21-29.
Chiba, K.; Sugihara, M.; Yoshida,K.; Mikami, M.; Kim, S.
Synthesis of Hydrophobic Phase-Tagged Prolyl Peptides Featuring Rapid Reac-tion/Separation,
Tetrahedron, 2009, 65, 8014-8020.
Okada,Y.; Akaba,R.; Chiba,K.
EC-backward-E Electrochemistry Sup-ported by an Alkoxyphenyl Group,
Tetrahedron Letters
, 2009, 50, 5413-5416.
Kim, S.; Chiba, K.
Solution-Phase Chemical Processes Featuring Facile Mul-ti-Step Reactions,
Journal of Synthetic Organic Chemistry, 2009, 67, 809-819.
Iijima, M.; Mikami, Y.; Yoshioka, T.; Kim, S.; Kamiya, H.; Chiba, K.
Rapid Magnetic Catch-and-Release Purification by Hydrophobic Interactions,
Langmuir, 2009, 25, 11043-11047.

Publication before 2009


小路 貴生, 金 承鶴, 千葉 一裕
Electrochemistry Vol. 83 (2015) No. 6 p. 467-471
Yohei Okada and Kazuhiro Chiba.
Biphasic Electrolytic System, Electrochemical Chain Reaction,
Encyclopedia of Applied Electrochemistry Savinell, R. F., Ota, K., Kreysa, G.,(eds).; Springer: Heidelberg, accepted. 
Yohei Okada and Kazuhiro Chiba (2012).
Electron Transfer Catalyzed Reaction,
Organic Electrochemistry, 5th ed.; Hammerich, O., Speiser, B.,(eds).; Taylor & Francis: New York, accepted.
Yohei Okada and Kazuhiro Chiba (2012).
Cyclohexane-Based Liquid-Biphasic Systems for Organic Electrochemistry,
Developments in Electrochemistry, Jang H. Chun.,(ed).; InTech, Chapter 4, 79-100, DOI:10.5772/53362.
Shingo Kitada, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba,
Practical Intramolecular Disulfide Formation Based on Hydrophobic Tag Strategy,
Peptide Science, 139-140, 2012, K. Sakaguchi,(eds). 
遺伝子医学MOOK21号特集「最新ペプチド合成技術と創薬研究への応用」編集 木曽良明 株式会社メディカルドゥ 2012, p.61-65. 
Kazuhiro Chiba and Yohei Okada (2012).
Electron-Transfer-Induced Intermolecular [2 + 2] Cycloaddition Reactions Assisted by Aromatic “Redox Tag”,
Recent Trend in Electrochemical Science and Technology, Ujjal Kumar Sur,(ed).; InTech, 91–106 DOI: 10.5772/33707.
有機合成化学協会誌、2009, 67, p 848 

Publication before 2009

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